Document 1147
 DOCN  M94A1147
 TI    26 cases of acute retinitis necrosis (ARN) in 26 HIV infected patients.
 DT    9412
 AU    Batisse D; Eliaszewicz M; Zazoun L; Baudrimont M; Dupont B; Hopital de
       l'Institut Pasteur, Paris, France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):198 (abstract no. PB0805). Unique
       Identifier : AIDSLINE ICA10/94371428
 AB    AIM: ARN, described till 1985 in non immuno-suppressed patients, occurs
       frequently in HIV infected population. Our aim was to report 26 cases of
       ARN in 26 HIV infected patients and to compare these data to literature.
       METHODOLOGY: We have conducted a retrospective study from 5
       ophtalmological departments (Paris, France). RESULTS: ARN was observed
       in patients with CD4 lymphocytes count under 100/mm3. Decreased vision
       was the first sign. Examination showed the characteristic triad:
       vitreous humor inflammation, arteritis and circumferantial afferent
       necrosis. In 60 to 90%, a viral vesicular eruption precedes of few days
       the ARN: in most cases VZV infection was concerned. Rarely, a
       neurological disease is associated. Bilateral (50%) blindness is the
       main complication (76 to 85%) due to detached retina. Our results
       suggest that VZV could be implicated in ARN. Diagnosis leads to an
       urgent anti-viral treatment. No drug is today efficient but foscarnet
       seems interesting, alone or in association (aciclovir, in situ
       ganciclovir).
 DE    Acute Disease  Human  HIV Infections/*COMPLICATIONS  Necrosis
       Retinitis/*COMPLICATIONS/DIAGNOSIS/MICROBIOLOGY  Retrospective Studies
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).