Document 1151
 DOCN  M94A1151
 TI    Stereology of the myocardium in AIDS/HIV+ patients.
 DT    9412
 AU    Paiva D; Lima DB; Gomes ND; Mandarim-de-Lacerda CA; Santos MB; State
       University of Rio de Janeiro, Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):197 (abstract no. PB0802). Unique
       Identifier : AIDSLINE ICA10/94371424
 AB    OBJECTIVE: Qualitative change in the myocardium has been described in
       patients as specific and non specific myocarditis, interstitial fibrosis
       and neoplasias. This study aims to determine some stereological
       parameters in the myocardium from AIDS/HIV+ patients. METHODS: Nine
       hearts from AIDS/HIV+ autopsies were studied: 7 men + 2 women, the mean
       age was 36.8 +/- 4.1 (SE). Three fragments of the superior portion of
       the cardiac left free wall were fixed (buffered 10% formaldehyde),
       serially sectioned (10 microns of thickness) and stained
       (haematoxylin-eosin). Ten pairs of optical disectors were studied to
       each case considering the vertical axis of the tissue. Counting in the
       look-up plane counted were considered to determine the numerical density
       of myocytes [Nv(m)]. The volume density was determined to myocytes
       [Vv(m)] and non-myocytes (connective tissue+vessels) [Vv(nm)] parts of
       the myocardium. Comparison of the results with normal myocardium has
       used the Mann-Whitney test. RESULTS: The means (+/- SE) of the values
       are: Nv(m) = 37,326.4 +/- 2,188.4 1/mm3; Vv(m) = 80.8 +/- 1.8% and
       Vv(nm) = 19.2 +/- 1.6%. DISCUSSION AND CONCLUSIONS: The figures found in
       this study are not significantly different from those described in
       normal myocardium (p > 0.05). The confidence interval at 95% of the
       values had great intersection between these two groups (AIDS/HIV+ and
       normal individuals). More research in a more important sample of cases
       is need to restudy this topic.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PATHOLOGY  Adult
       Female  Heart Diseases/COMPLICATIONS  Human  HIV
       Seropositivity/*PATHOLOGY  Male  Myocardium/*PATHOLOGY  MEETING ABSTRACT

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