Document 1152
 DOCN  M94A1152
 TI    Fever of unknown origin in HIV-infected patients. A
       multicentric-prospective study of 116 cases. Andalusian Group for Study
       of Infectious Diseases.
 DT    9412
 AU    Lozano F; Pujol E; Torres-Cisneros J; Bascunana A; Canas E;
       Garcia-Ordonez MA; Hernandez-Quero J; Vergara A; Marquez M; Diez F; et
       al; Hospital General de Huelva, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):197 (abstract no. PB0803). Unique
       Identifier : AIDSLINE ICA10/94371423
 AB    OBJECTIVE: HIV-associated FUO is an entity with peculiar significance
       and not yet adequately studied till now. Our purpose was to document the
       occurrence, etiology, prognosis and profitability diagnosis of FUO.
       METHODS: A prospective 2-year (92-93) study was realized with 116
       in-patients from 14 hospitals of Andalusia. They fullfilled following
       criterion: 1) Proved HIV infection, 2) Fever > 38.3 degrees C, more of
       three weeks of duration, 3) Not etiologic diagnosis after one week
       hospitalization, 4) Not evidence of clinical or radiologic data of focal
       point infection at admission moment. RESULTS: Frecuency of
       HIV-associated FUO was 3.1%. The average patient's age was 31.2 + 8.4
       years. 88% of them were males, 82% intravenous drug abusers and 40% were
       AIDS diagnosis previously. Mean duration of fever and hospitalization
       was 68 + 38.3 days and 40.1 + 25.3 respectively. Mean number of CD4
       lymphocites was 98.7 + 145/mm3 (76% had < 100/mm3 and 59% had < 50/mm3).
       A sure diagnosis was achieved in 75% of patients. Most common entities
       were: tuberculosis (37%), visceral leishmaniasis (19%), MAI infection
       (8%) and lymphomas (7%). Diagnosis was probably suspected in 19% of
       patients (tuberculosis was suspected in 65% of them) and in a 6% any
       etiologic diagnosis was obtained. The most valuable investigations was
       hepatic biopsy (67%) and bone marrow puncture (38%). During
       hospitalization period 10% of patients died. DISCUSSION AND CONCLUSIONS:
       1) HIV-associated FUO is a relatively common entity that appears in
       advanced HIV-infection and bears a high economic cost. 2) More prevalent
       etiologies in our country are tuberculosis and visceral leishmaniasis.
 DE    Adult  AIDS-Related Opportunistic Infections/COMPLICATIONS  Female
       Fever of Unknown Origin/*ETIOLOGY  Human  HIV Infections/*COMPLICATIONS
       Lymphoma, AIDS-Related/COMPLICATIONS  Male  Prospective Studies  MEETING
       ABSTRACT  MULTICENTER STUDY

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