Document 1162
 DOCN  M94A1162
 TI    Human CRH test in AIDS.
 DT    9412
 AU    Galhardo MC; Cuba J; Veloso VG; Moreira RB; Cavalcante SC; Grinaztejn B;
       Tendrich M; Evandro Chagas Hosp. IOC/FIOCRUZ/BARZIL.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):195 (abstract no. PB0794). Unique
       Identifier : AIDSLINE ICA10/94371413
 AB    20 patients with AIDS (IV Group, CDC, 1987) were submitted to
       stimulation with human CRH (100mg EV route) in order to evaluate the
       function of hypothalamus-hypophysis-Adrenal-Axis (HHAA). Basal and
       post-hCRH: ACTH, Cortisol(F) and Aldosterone (A) plasmatic levels were
       performed. Results. Normal response of ACTH, together with normal
       response of F and A (35%), and hyporesponse only of A (5%), hyporesponse
       of ACTH associated with normal response of F and A (5%) with
       hyporesponse of F (5%) and A (5%) and of both hormones (10%), and
       finally hyper response of ACTH with hyporesponse of F and A (35%)
       Conclusions: It was possible to diagnose disfunctions of HHAA low
       reserve of the hypothalamus and hypophysis and subclinical adrenal
       insufficiency using hCRH test in patients with AIDS.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*PHYSIOPATHOLOGY
       Aldosterone/BLOOD  Corticotropin/BLOOD  Corticotropin-Releasing
       Hormone/*DIAGNOSTIC USE  Human  Hydrocortisone/BLOOD
       Hypothalamo-Hypophyseal System/*PHYSIOPATHOLOGY  Pituitary-Adrenal
       System/*PHYSIOPATHOLOGY  MEETING ABSTRACT

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