Document 1167
 DOCN  M94A1167
 TI    The effect of human immunodeficiency virus infection on the course of
       pelvic inflammatory disease.
 DT    9412
 AU    Biggers SD; Laguardia KD; Laguardia, KD-New York Hospital Cornell
       Medical Center NYC.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):193 (abstract no. PB0787). Unique
       Identifier : AIDSLINE ICA10/94371408
 AB    OBJECTIVE: Seroprevalence studies have indicated that HIV infection is
       considerably higher amongst women admitted to gyn services with PID than
       in the normal population. This study will further characterize the
       course of PID in HIV infected women admitted to The New York Hospital
       gynecology service. METHODS: Study population: Eighty-one patients
       admitted to NYH gyn service between 12/90 and 2/94 were counseled for
       HIV testing. Seventy-one patients accepted the test and 12 were HIV
       positive. (16.9%) Study type: Case-control: 12 HIV+ cases were compared
       to 59 HIV- controls admitted to the NYH gyn service with PID during the
       same time period. Variables evaluated were gonorrhea (GC), Chlamydia,
       VDRL status and admission WBC as well as the rate of tubo-ovarian
       abcesses (TOA's), the necessity for surgical intervention and the length
       of hospital stay. Statistical analysis: Categorical variables correlated
       using Chi-square analysis, continuous data evaluated with Student t
       test. RESULTS: There were no significant correlations between HIV
       seropositivity and age, GC and Chlamydia status, or the necessity for
       surgical intervention. There were significant positive correlations
       between HIV seropositivity and +VDRL status (OR = 20.4 p < .005),
       admission WBC < 10 (OR = 3.6, p < .005), and the rate of tubo-ovarian
       abscesses (TOA's) (OR = 11.4 p < .005). The mean length of hospital stay
       was significantly longer for HIV+ patients versus HIV- patients (9.5 +/-
       4.4 vs 6.6 +/- 3.5 p < .001). DISCUSSION AND CONCLUSIONS: Women admitted
       to gynecological services with PID are at high risk for HIV infection.
       In this analysis, HIV+ patients with PID had a lower admission WBC, were
       more likely to have TOA's and consume more hospital days than HIV-
       patients. There was no evidence for an increased necessity for surgical
       intervention in HIV+ patients. These data suggest that although HIV+
       patients may be admitted with a lower WBC, they have a higher chance of
       having a severe course of PID. They also appear to respond to
       conservative therapy as opposed to early surgical intervention. Further
       studies are required to examine outcome associated with type of
       intervention in this population.
 DE    Abscess/COMPLICATIONS  Adnexitis/*COMPLICATIONS  Chlamydia
       Infections/COMPLICATIONS  Female  Gonorrhea/COMPLICATIONS  Human  HIV
       Infections/*COMPLICATIONS  HIV Seropositivity  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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