Document 1168
 DOCN  M94A1168
 TI    Postoperative complications of gynecological and obstetrical patients
       with HIV-infection.
 DT    9412
 AU    Dathe O; Grubert T; Lutz-Friedrich R; Stauber M; 1st Department of
       Gynecology and Obstetrics, Univ. of Munich,; Germany.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):193 (abstract no. PB0784). Unique
       Identifier : AIDSLINE ICA10/94371407
 AB    OBJECTIVE: In a retrospective comparative study we followed the rate of
       complications after various obstetrical and gynecological operations in
       HIV-infected female patients. METHODS: 95 female patients of the
       University Hospital in different stages of HIV-disease underwent 140
       surgeries between 1985 and 1992. Matched pairs of non-HIV-infected women
       with equal procedures were set up retrospectively. RESULTS: In a total
       of 140 operations on 95 patients we found an overall complication rate
       of 17%, which was markedly higher than the rate in our matched-pair
       control group. Following surgery, fever was observed in 12%. In 4% we
       found healing impairment, in an additional 4% of the patients secondary
       surgery was necessary. The rate of complications correlated directly
       with the CDC-stage of the patient at the time of the operation. We also
       found an increased complication rate in patients with low preoperative
       immunological status, expressed in CD4-counts and CD4/CD8 ratio as well
       as functional lymphocyte testing. Long duration of infection was
       connected with an increased complication rate. Especially following
       major operations, such as hysterectomy, cesarian section and other
       laparotomies the complication rate was high. CONCLUSION: We would like
       to emphasize that in particular for major gynaecological and obstetrical
       operations accurate diagnosis is imperative. In those patients, as well
       as in patients with reduced immunological status we recommend a
       prophylactic treatment with broad spectrum antibiotics in order to
       reduce the postoperative complication rate.
 DE    Comparative Study  CD4-CD8 Ratio  Female  Genital Diseases,
       Female/*SURGERY  Human  *HIV Infections/COMPLICATIONS/IMMUNOLOGY
       *Postoperative Complications  Pregnancy  Pregnancy
       Complications/*SURGERY  Pregnancy Complications, Infectious
       Retrospective Studies  MEETING ABSTRACT

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