Document 1170
 DOCN  M94A1170
 TI    Disease progression in HIV1 infected women after delivery. A case
       control study.
 DT    9412
 AU    Bongain A; Durant J; Zammit V; Dellamonica P; Gillet JY; Dpt of
       Obstetrics-Gynecology, University of Nice, France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):193 (abstract no. PB0786). Unique
       Identifier : AIDSLINE ICA10/94371405
 AB    OBJECTIVE: To estimate survival and disease progression in human
       immunodeficiency virus antibody-positive pregnant women. METHODS: We
       compare, by case control, clinical and laboratory parameters of 120 HIV1
       antibody-positive women: 60 were pregnant and delivered a viable infant
       at least 28 weeks of amenorrhea and 60 were non-pregnant. All the
       patients were followed at the Hospital of Nice, France (mean: 49.9 +/-
       20 months, min: 1, max: 120). Survival and disease progression were
       estimated by Kaplan-Meier analysis and linear regression. All p values <
       0.05 were considered statistically significant. RESULTS: No
       statistically significant differences between the two population
       regarding age, beginning of HIV infection, zidovudine or others
       therapies, CD4 cells count at inclusion, and CDC stages were observed.
       No statistically significant differences were noted regarding the number
       of opportunistic and secondary infections. The cumulative probability of
       survival, at the end of this study (June, 30th, 1993), with Kaplan-Meier
       analysis, is not statistically different among the two groups. But,
       there were statistically significant differences regarding the depletion
       of CD4 cells count (y = -4,6x + 463 vs y = -1,4x + 519). CONCLUSION: Old
       studies of HIV1 infected pregnant women have overestimated progression
       and underestimated survival. Our data find pregnancy accelerate the
       HIV-induced depletion of CD4 lymphocytes but not increase the risk of
       progression to AIDS. It'll be necessary to follow up this study to
       estimate survival and disease progression during a longer period.
 DE    Case-Control Studies  Female  Human  HIV Infections/MORTALITY/*PATHOLOGY
       HIV Seropositivity/PATHOLOGY  *HIV-1  Infant, Newborn  Pregnancy
       *Pregnancy Complications, Infectious  Prognosis  Survival Rate  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).