Document 1171
 DOCN  M94A1171
 TI    Serological markers of CMV-infection in Russian HIV-infected patients;
       relation with clinical manifestations.
 DT    9412
 AU    Ermak TN; Schahglidjan VI; Kravchenko AV; Stakhanova VM; Karagas NV;
       Ribalkina TI; Pokrovsky VV; Russian AIDS Centre, Moscow.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):192 (abstract no. PB0781). Unique
       Identifier : AIDSLINE ICA10/94371404
 AB    OBJECTIVE: To determine CMV-infection incidence among HIV-patients in
       Russia and relations between serological markers and clinical signs of
       CMV-infection. MATERIALS AND METHODS: During 1993 110 pts. have been
       examined: 94 adults, 16 children (LAP--32; ARC--60; AIDS--18) for
       anti-CMV IgM and IgG with ELISA. RESULTS: In 5 pts. (4.5%), including 2
       children, have not been revealed anti-CMV of both classes. Anti-CMV IgM
       have been revealed in 26 (24.8%) pts. (LAP--3; ARC--15; AIDS--8).
       Dinamic titres of anti-CMV IgG in this pts. were different. 1-st group
       (14 pts.--53.8%) had either increase or repeated high titres of anti-CMV
       IgG. In this group presented pneumonia (9), colitis (5), retinitis (3);
       in 5 pts. have been revealed combination of these syndroms. 2-nd group
       (2 pts. 7.7%) had not anti-CMV IgG at first examination, but in clinical
       manifestation they showed pharyngitis, increase of neck lymphatic nodes,
       hepato-splenomegalia. After 2-3 months they showed appearance of
       anti-CMV IgG in high titres. 3-rd group (7.7%--2 AIDS pts. with clinical
       signs of CMV-infection: retinitis, pneumonia, colitis and number of CD4
       < 20 x 10(6)/l) had steadfast decrease of anti-CMV IgG titres. 4-th
       group (8 pts.-30.8%) had low anti-CMV IgG titres without tendency to
       change and minimum clinical signs. The rest of all (79 pts.-75.2%) pts.
       (in 6 of them were anti-CMV IgG and in 4 of them had increase of
       anti-CMV IgG more than 4 times) had not clinical manifestations of
       CMV-infection. CONCLUSION: 95.5% examened HIV-pts. In Russia have
       CMV-infection, and in the majority of pts. (77.3%) it has latent course.
       Increase of anti-CMV IgG titres and availability of anti-CMV IgM can
       show the relaps of diseases. It requires more reliable testing
       (virological, histological). Results are being studied at present time.
       Decrease of anti-CMV IgG titres in pts. with retinitis can be
       conditioned by deficiency of immune response in terminal AIDS stage.
 DE    Acquired Immunodeficiency Syndrome/BLOOD  Adult  Antibodies,
       Viral/*BLOOD  AIDS-Related Complex/BLOOD  AIDS-Related Opportunistic
       Infections/BLOOD/*DIAGNOSIS/  EPIDEMIOLOGY  Biological Markers/*BLOOD
       Child  Cytomegalovirus Infections/BLOOD/*DIAGNOSIS/EPIDEMIOLOGY
       Enzyme-Linked Immunosorbent Assay  Human  IgG/BLOOD  IgM/BLOOD
       Incidence  Russia/EPIDEMIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).