Document 1172
 DOCN  M94A1172
 TI    Pregnancy and HIV-infection in Ugandan women.
 DT    9412
 AU    Naamara W; Katabira P; Reingold A; Hearst N; M.O.H. Uganda.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):192 (abstract no. PB0782). Unique
       Identifier : AIDSLINE ICA10/94371403
 AB    OBJECTIVE: To determine the effect of pregnancy on HIV-1 Infection.
       METHODS: Women of ages between 15-49 years attending the AIDS clinic in
       Kampala, Uganda were staged for AIDS based on the CDC clinical criteria
       and clinical assessment. Demography, pregnancy history, and outcome were
       recorded. RESULTS: 114 women were studied, mean age 26.7 +/- 5, mean
       number of pregnancies were 3.6 +/- 2.8. 7% were stage 1, 60% stage 2,
       26.1% stage 3, and 5.2% stage 4. As expected, there was a strong
       association between age and number of pregnancies (p = 0.0001). There
       was no strong association between stage of disease and age. Neither was
       there a strong association between stage and unstratified number of
       pregnancies. When previous pregnancies was stratified as 1 versus more
       than one and compared to stages of disease, those with more than one
       pregnancy had significantly more advanced disease (p = .008). This trend
       was strongest in younger women. DISCUSSION AND CONCLUSION: Our study
       design did not allow a definite determination of the association between
       pregnancy and HIV-disease progression. There is a suggestion of an
       association between numbers of pregnancies and stage in the 18-20
       year-olds. This could be due to small numbers, or could suggest that
       younger women may be at an increased risk of faster progression to
       disease with repeated pregnancies. This calls for more analytical
       studies to determine appropriate messages to give infected women
       regarding pregnancy and HIV disease progression.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY  Adolescence  Adult
       Age Factors  Comparative Study  Female  Human  *HIV-1  Middle Age
       Pregnancy  Pregnancy Complications, Infectious/*EPIDEMIOLOGY  Pregnancy
       Outcome  Uganda/EPIDEMIOLOGY  MEETING ABSTRACT

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       protected by Copyright Law (Title 17, U.S.Code).