Document 1175
 DOCN  M94A1175
 TI    No additional expansion of immune activation parameters in 264 AIDS
       patients with opportunistic infections (OI) as compared to patients with
       AIDS due to OI but without actual OI.
 DT    9412
 AU    Bogner JR; Sadri I; Kinzel D; Geier SA; Goebel FD; Medizihische
       Poliklinik, University of Munich, Germany.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):191 (abstract no. PB0777). Unique
       Identifier : AIDSLINE ICA10/94371400
 AB    OBJECTIVE: To investigate whether expansion of parameters indicative of
       immunologic activation--as communicated previously--is due to late stage
       HIV-disease per se or whether it reflects additional activation due to
       immune responses against opportunistic infections.
       MEASUREMENTS/PATIENTS: Lymphocyte subsets (absolute number/microliter)
       CD4+, CD3+ HLADR+, CD3+ CD57+; serum Neopterin (NPT) (nmol/L), beta 2
       microglobulin (beta 2) (mg/dl), and gammaglobulins (%); 357 patients
       with AIDS as defined by OI. Grouping of OI and patients numbers see
       table below (means +/- SD). RESULTS: For each variable one-way analysis
       of variance revealed that none of the OI and none of the parameters
       showed significant differences as compared to a group of AIDS patients
       without actual OI (group 6). TABULAR DATA, SEE ABSTRACT VOLUME.
       CONCLUSIONS: Expansion of the investigated activation parameters in AIDS
       (Group CDC C3 with OI) seems to be due to activation by HIV, rather than
       to additional immunological responses upon opportunistic pathogens.
 DE    beta 2-Microglobulin/ANALYSIS  Acquired Immunodeficiency
       Syndrome/BLOOD/*IMMUNOLOGY  Analysis of Variance  Antigens, CD/*BLOOD
       AIDS-Related Opportunistic Infections/BLOOD/*IMMUNOLOGY  Biological
       Markers/BLOOD  Biopterin/ANALOGS & DERIVATIVES/BLOOD
       Candidiasis/BLOOD/IMMUNOLOGY  Comparative Study  Cytomegalovirus
       Infections/BLOOD/IMMUNOLOGY  Gamma Globulins/ANALYSIS  Human  Lymphocyte
       Subsets/*IMMUNOLOGY  *Lymphocyte Transformation  Mycobacterium
       avium-intracellulare Infection/BLOOD/IMMUNOLOGY  Pneumonia, Pneumocystis
       carinii/BLOOD/IMMUNOLOGY  Toxoplasmosis, Cerebral/BLOOD/IMMUNOLOGY
       MEETING ABSTRACT

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