Document 1179
 DOCN  M94A1179
 TI    Proinflammatory cytokines in HIV patients.
 DT    9412
 AU    Ketlinsky SA; Kalinina NM; Prokopieva ED; Chaldeeva NA; Institute of
       Pure Biochemicals, S.-Petersburg, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):190 (abstract no. PB0772). Unique
       Identifier : AIDSLINE ICA10/94371396
 AB    OBJECTIVE. The goal of the research is to determined role of
       proinflammatory cytokines in HIV pathogenesis. METHODS. IL-1b, -6 &
       TNF-a production, spontaneous and after PMA (5 ng/ml) stimulation, by
       PMBC of 34 adults and 16 children were measured in ELISA & biotest. Data
       were compared with the same in healthy persons, 42 children & 38 adults.
       Data reliability confirmed by t Student criteria. RESULTS. Spontaneous
       IL-1b, -6 & TNF-a production by PMBC of HIV patients were statistically
       higher, when in healthy persons (p < 0,05). TABULAR DATA, SEE ABSTRACT
       VOLUME. If the spontaneous levels of PMBC cytokine production were HIGH,
       PMA stimulation led to a decreasing of cytokine production, but in
       contrast if the spontaneous production were low PMA increased cytokine
       production. High spontaneous levels of IL-1b, -6 & TNF-a correlated with
       severity of ilness & progression of desease. The high correlation
       observed with p24 attigenemia. CONCLUSIONS. Proinflamatoty cytokines
       playing the important role inpathogenesis of HIV infection & spontaneous
       production reflect the severity of illness.
 DE    Adult  Age Factors  Cells, Cultured  Child  Comparative Study  Human
       HIV Infections/*IMMUNOLOGY  HIV Seronegativity/*IMMUNOLOGY
       Interleukin-1/*BIOSYNTHESIS  Interleukin-6/*BIOSYNTHESIS
       Lymphocytes/DRUG EFFECTS/*IMMUNOLOGY  Reference Values
       Tetradecanoylphorbol Acetate/PHARMACOLOGY  Tumor Necrosis
       Factor/*BIOSYNTHESIS  MEETING ABSTRACT

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