Document 1182
 DOCN  M94A1182
 TI    Antiphospholipid antibody syndrome (APS) in ARC and AIDS patients.
 DT    9412
 AU    Gritti Francesco M; Fondacaro A; Bini A; Guerra L; Cannella B; Cicognani
       M; Schiattone ML; Raise E; Inf. Dis. Dpt., Maggiore Hospital, Bologna,
       Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):190 (abstract no. PB0774). Unique
       Identifier : AIDSLINE ICA10/94371393
 AB    OBJECTIVES: antiphospholipid antibodies (AP) appear in patients (pts)
       with autoimmune disorder, such as systemic lupus erithematosus and HIV1
       infection. The aim of our study is to investigate the presence of APS in
       HIV1 positive pts with ARC or AIDS and correlation between them and the
       clinical pictures. MATERIALS AND METHODS: 14 AIDS (CDC 4 C1) and 5 ARC
       (CDC 4 C2) showed some clinical and laboratoristic criteria for the
       identification of APS; the evaluation of the AP was performed by IgG-IgM
       Elisa, VDRL, lupus anticoagulant activity (LAC), antibody anti
       platelets. RESULTS: 19/19 pts (AIDS and ARC) had fever, headache (7
       pts), paresis (7), cranial nerve involvement (3), Raynaud S. (2), deep
       vein and arterial trombosis (2), disseminated intravascular coagulation
       (2), encephalitis (1). The concomitant infections were cytomegalovirus
       dissemination (6) and MAC infection (4). All pts were positive to IgG or
       IgM while VDRL and LAC were positive only in 5/18. Tc and magnetic
       resonance of the brain were positive in 1 pt with neurological symptoms.
       Corticosteroid and anticoagulant therapy improved the clinical picture
       with disappearance of fever (19/19), partial or total resolution of
       neurological and vascular injures. CONCLUSIONS: 1) The APS emerges
       especially in advanced stage of HIV1 infection. 2) The neurological and
       vascular symptoms are the most common findings. 3) the absence of
       evident brain lesions, except in one pt, is usual. 4) The symptoms
       associated to platelet number reduction and PTT alteration are the guide
       towards the APS diagnosis.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY/  PHYSIOPATHOLOGY
       Antibodies, Antiphospholipid/BLOOD  Antiphospholipid
       Syndrome/*BLOOD/DIAGNOSIS/ETIOLOGY  AIDS-Related
       Complex/BLOOD/*IMMUNOLOGY/PHYSIOPATHOLOGY  Human  IgG/BLOOD  IgM/BLOOD
       MEETING ABSTRACT

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