Document 1188
 DOCN  M94A1188
 TI    Iron stores and anemia in HIV-1 infection.
 DT    9412
 AU    Velati C; Macagni A; Vismara L; De Ferrari C; Lobbiani A; Galli M;
       Musicco M; Fiorelli G; Centro Immunotrasfusionale, Ospedale Caduti
       Bollatesi, Bollate; (MI), Italia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):189 (abstract no. PB0770). Unique
       Identifier : AIDSLINE ICA10/94371387
 AB    OBJECTIVE: Anemia is the most frequent cytopenia in AIDS and seems to
       correspond to the infection stage. Among different mechanisms involved,
       an important one is the activation of reticuloendothelial system which
       could altere the iron status. METHODS: We studied hematological indices,
       iron status parameters, and some immunological indices of disease
       progression, lymphocytic subset and beta 2-microglobulin in 174 HIV-1
       positive subjects (31 asymptomatics, 96 LAS, 32 ARC, 15 AIDS) and 19
       high risk seronegative controls never treated with anti-retroviral nor
       myelosuppressive drugs. RESULTS: Hb, Ht, serum iron and transferrin were
       progressively reduced in relation to the disease stage whereas ferritin
       was increased. CD4+ lymphocytes and beta 2-microglobulin values
       correlate significantly with Red Blood Cells (p < 0.001), Hematocrit (p
       < 0.001), serum iron (p < 0.001) and ferritin (p < 0.01). DISCUSSION:
       The relationship observed among anaemia, iron status and immune
       activation in HIV-1 infected persons, suggests that the activation of
       the immune system should be considered a possible cause of impaired
       erythropoiesis.
 DE    beta 2-Microglobulin/ANALYSIS  Acquired Immunodeficiency
       Syndrome/*BLOOD/IMMUNOLOGY  Anemia/*ETIOLOGY  AIDS-Related
       Complex/*BLOOD/IMMUNOLOGY  Biological Markers  Comparative Study
       Erythropoiesis  Ferritin/BLOOD  Hematocrit  Human  HIV
       Seronegativity/IMMUNOLOGY/*PHYSIOLOGY  HIV
       Seropositivity/*BLOOD/IMMUNOLOGY  *HIV-1  Iron/*BLOOD  Leukocyte Count
       Lymphocyte Subsets/IMMUNOLOGY  Risk-Taking  T4 Lymphocytes  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).