Document 1189
 DOCN  M94A1189
 TI    HLA phenotypes & TNF-a production in HIV patients.
 DT    9412
 AU    Kalinina NM; Ketlinsky SA; Bubnova LN; Rachmanova AG; Institute of Pure
       Biochemicals, S. Petersburg, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):189 (abstract no. PB0771). Unique
       Identifier : AIDSLINE ICA10/94371386
 AB    OBJECTIVE. The goal of research were to determine HLA predisposition to
       illness progression which realised throw high or low levels of TNF-a
       production, the pathogenic factor of HIV infection. METHODS. HLA
       phenotypes of 100 HIV patients were determined by serological methods.
       The 57 adult & 43 children with HIV infection were investigated. The
       control group consisted of 454 healthy adults and 50 children,
       inhabitants of the same country regions. TNF-a in all cases were
       measured by ELISA. Data reliability confirmed by t Student & chi 2
       criteria. RESULTS. Frequences of HLA A25, B51, DR 5, 6 antigens were
       statistically higher & B15 in conirary lower than incontrol group. HLA
       A25, B13 were observed statistically frequently in group of high
       producers of TNF-a, 6 HLA-DR5, 6 in group of low producers of TNF-a.
       CONCLUSIONS. Obtained data indicates that genetic HLA factors may play
       role in pathogenesis of HIV infection.
 DE    Adult  Child  Enzyme-Linked Immunosorbent Assay  Human  HIV
       Infections/BLOOD/*IMMUNOLOGY  HLA-A Antigens/*BLOOD  HLA-B
       Antigens/*BLOOD  HLA-DR Antigens/*BLOOD  Immunophenotyping  Reference
       Values  Tumor Necrosis Factor/ANALYSIS/*BIOSYNTHESIS  MEETING ABSTRACT

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