Document 1192
 DOCN  M94A1192
 TI    Morphology of blood platelets and their functional condition in
       HIV-infected patients.
 DT    9412
 AU    Polyakova AM; Astrina OS; Kravchenko AV; Maleev VV; Central Institute of
       Epidemiology, Moscow, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):188 (abstract no. PB0764). Unique
       Identifier : AIDSLINE ICA10/94371383
 AB    OBJECTIVE: To study platelet forms and their function in HIV-infected
       patients depending on the disease stage. METHODS: Calculation of
       thrombocytes, secretory reaction (exocytosis), ATP content (adenosine
       triphosphate, luciferin-luciferase method), morphology of platelets
       (intact and spheroid forms--electronscane microscopy). RESULTS: 60
       HIV-infected adults: ARC--45 (1-st group), AIDS--15 (2-nd group) were
       enrolled in the study. Middle count of CD4--269.1 +/- 40.4 x 10(6)/l--1
       gr.:--57.6 +/-17.4 x 10(6)/l--2 gr. (p < 0.01). TABULAR DATA, SEE
       ABSTRACT VOLUME. CONCLUSIONS: The progress of HIV-infection leads to the
       supression of platelet functional activity: decrease of secretory
       capacity and maintenance of ATP. At the same time the count of spheroid
       (functional compromised) platelets is increased.
 DE    Adenosine Triphosphate/BLOOD  Blood
       Platelets/*PATHOLOGY/*PHYSIOLOGY/ULTRASTRUCTURE  Exocytosis  Human  HIV
       Infections/*BLOOD  Microscopy, Electron, Scanning  Platelet Count
       MEETING ABSTRACT

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