Document 1193
 DOCN  M94A1193
 TI    Fungal bone marrow cultures and platelets.
 DT    9412
 AU    Ramirez-Ronda R; Nieves E; Del Valle C; Aponte A; Santos M; Immunology
       Clinic OCASET, Cabo Rojo, PR.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):188 (abstract no. PB0766). Unique
       Identifier : AIDSLINE ICA10/94371382
 AB    OBJECTIVE: It is well known that HIV infection is linked to other
       disorders. Thrombocytopenia has been described in these patients but the
       precise mechanism of it has not been established. It is the purpose of
       this study to evaluate possible etiologies of thrombocytopenia in HIV
       patients seen at our clinic. METHODS: Fifteen HIV seropositive patients
       free of systemic infections at the moment of the study and with
       thrombocytopenia below 100,000 underwent bone marrow aspiration. Samples
       from aspirate were taken in several culture media to asses the presence
       of bacterial, mycobacterial and fungal infection. RESULTS: Bone marrow
       examination revealed the presence of hypoplasia in 66.7%, 20% showed
       myelofibrosis, 6.7% had ITP and 6.7% secondary thrombocytopenia. In the
       review of culture reports was found that 46.7% of participants had
       positive bone marrow fungal cultures. Fungi in the bone marrow was
       associated with past history of superficial mycosis. This group had the
       highest platelet count belonging 71.4% of them to the hypoplasia group.
       CONCLUSION: In the HIV patient with thrombocytopenia the bone marrow
       examination with cultures gives a high yield and fungi were frequently
       found in the population studied.
 DE    AIDS-Related Opportunistic Infections/*BLOOD/*PATHOLOGY  Bone
       Marrow/MICROBIOLOGY/*PATHOLOGY  Cells, Cultured  Comparative Study
       Human  HIV Seropositivity/*BLOOD/COMPLICATIONS/*PATHOLOGY
       Mycoses/BLOOD/*COMPLICATIONS/PATHOLOGY
       Thrombocytopenia/BLOOD/*COMPLICATIONS/PATHOLOGY  MEETING ABSTRACT

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