Document 1194
 DOCN  M94A1194
 TI    Fever plus neutropenia in AIDS patients: etiology and response to G-CSF.
       Andalousian Infectious Diseases Group (GAEI).
 DT    9412
 AU    Hernandez-Quero J; Viciana P; Villanueva J; Vergara A; Giron JA; Lozano
       F; Infectious Unit, Hospital Clinic San Cecilio, Granade, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):188 (abstract no. PB0767). Unique
       Identifier : AIDSLINE ICA10/94371381
 AB    OBJECTIVE: To describe the etiology of fever in neutropenic
       HIV-pacients, and to analyze the G-CSF treatment. METHODS: Open
       non-comparative study. Patients with fever (> 38 degrees C) plus
       neutropenia (< 750/microliters absolute neutrofil count (ANC)) due to
       any cause, and HIV infection were included. All the patients gave
       informed consent. G-CSF was administered (0.5 MU/Kg) once-a-day for at
       least 3 days, and it was discontinued ANC were higher than 2000cells
       mu/l (response- > R). Blood cell count were performed at 3, 7, 14, 21,
       28 days after the start of treatment. Studies looking for fever causes
       was done. RESULTS: 25 patients were enrolled, 20 with AIDS an 5 with
       ARC. The mean CD4 cell was 50 +/- 70 microliters. 17/25 had bacterial
       infections, 4 had Leishmaniasis and 3 lymphoma. Responders (R) were 20
       (80%), 10 of them in the 3th day and 16/20 in the first week. The mean
       duration of G-CSF treatment was 8,7 +/- 5 days. Four patients reported
       local pain during injection without other side effects. Eight patients
       (32%) died, without difference among R and non-R. In all the survivars
       the neutropenia and the fever resolved. TABULAR DATA, SEE ABSTRACT
       VOLUME. CONCLUSIONS: Bacterial infections are predominant in febril HIV
       neutropenia. Short courses of G-CSF may be beneficial in these patients,
       but it's necessary to initiate controlled studies to evaluate the
       survival efficacy.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/
       *PHYSIOPATHOLOGY  AIDS-Related Opportunistic Infections/BLOOD/MORTALITY/
       *PHYSIOPATHOLOGY  Bacterial
       Infections/BLOOD/COMPLICATIONS/PHYSIOPATHOLOGY  Fever/*ETIOLOGY/THERAPY
       Granulocyte Colony-Stimulating Factor/*THERAPEUTIC USE  Human
       Leishmaniasis/BLOOD/COMPLICATIONS/PHYSIOPATHOLOGY  Leukocyte Count
       Neutropenia/*ETIOLOGY/THERAPY  Survival Rate  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).