Document 1197
 DOCN  M94A1197
 TI    Reduction of CD8+ cell count develops thrombocytopenia in HIV-infected
       hemophiliacs.
 DT    9412
 AU    Tokumaru O; Ohji T; Shirahata A; Department of Pediatrics, School of
       Medicine, University of; Occupational and Environmental Health Japan,
       Kitakyushu.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):187 (abstract no. PB0762). Unique
       Identifier : AIDSLINE ICA10/94371378
 AB    OBJECTIVE: Many types of autoimmune disease occur in HIV-infected
       patients. It is not clear what factors are involved in the mechanism of
       their occurrence. To address the problem, we investigated the
       HIV-infected hemophiliacs with thrombocytopenia, as a manifestation of
       autoimmune disease, and those without it. METHODS: Thirty five
       hemophiliacs with HIV infection enrolled this study. Thirty two of them
       were in CDCP Group A and three were in Group C. The patients with
       thrombocytopenia met the following criteria: platelet counts less than
       150,000 (/microliter): no concomitant opportunistic infection: no acute
       hemorrhage. A complete blood count, lymphocyte subsets (CD4+, CD8+),
       liver function tests (GOT, GPT, LDH, cholinesterase), serum
       immunoglobulins (IgG, IgM, IgA) and serum beta 2-microglobulin were
       measured. Analytic procedures were carried out using the StatView
       software package (Abacus Concepts Inc., CA, USA). RESULTS: 1) Fourteen
       (43.8%) of 32 in CDCP Group A had thrombocytopenia, and all (100%) of
       three in Group C did it. To exclude the influence of clinical advance,
       the following analysis were performed in only 32 patients of Group A. 2)
       In 14 patients with thrombocytopenia (Group I), both mean CD4+ and CD8+
       cell counts were significantly less than those in 18 without
       thrombocytopenia (Group II) (unpaired t-test, p < 0.05), however there
       were no significant differences in other cell counts between two groups.
       In Group I, serum GOT significantly increased (p < 0.05) and serum
       cholinesterase significantly decreased (p < 0.05), compared with those
       in Group II. 3) Stepwise regression analysis showed that both CD8+ cell
       counts (F = 9.22) and serum cholinesterase (F = 9.17) were significant
       determinants of platelet counts in all 32 patients. A linear correlation
       was noted between CD8+ cell and platelet counts (r = 0.499, p < 0.01).
       DISCUSSION AND CONCLUSIONS: Thrombocytopenia in HIV-infected
       hemophiliacs was possibly dependent on suppressor T cell count and liver
       function. These results provide a hypothesis that reduction of
       suppressor T cell may be attributed to the occurrence of autoimmune
       disease in HIV-infected patients.
 DE    Antigens, CD/*BLOOD  Antigens, CD4/BLOOD  Antigens, CD8/*BLOOD
       Comparative Study  Hemophilia/BLOOD/COMPLICATIONS/*IMMUNOLOGY  Human
       HIV Infections/BLOOD/COMPLICATIONS/*IMMUNOLOGY  Leukocyte Count  Liver
       Function Tests  Regression Analysis  T-Lymphocyte Subsets/*IMMUNOLOGY
       T-Lymphocytes, Suppressor-Effector/*IMMUNOLOGY
       Thrombocytopenia/BLOOD/ETIOLOGY/*IMMUNOLOGY  T4 Lymphocytes  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).