Document 1198
 DOCN  M94A1198
 TI    Low serum G-CSF level in HIV positive hemophiliacs as a cause of
       neutropenia.
 DT    9412
 AU    Hanabusa H; Matsuda F; Miura T; Department of Pediatrics, Ogikubo
       Hospital, Tokyo, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):187 (abstract no. PB0760). Unique
       Identifier : AIDSLINE ICA10/94371377
 AB    OBJECTIVE: Among 91 HIV positive hemophiliacs, 10 patients with
       neutropenia who were intractable with chemotherapy and treated with
       rG-CSF during the period from 1989 to 1993 were investigated. METHODS:
       In patients with a decreased neutrophilic count of 1,000/microliter on
       below, serum G-CSF level was measured by EIA method. Pharmacokinetic
       examination in blood was performed after administration of rG-CSF 5
       micrograms/kg. RESULTS: Serum G-CSF level was below the detection limit
       of 39.1 pg/ml in 8 out of the 10 cases. Among the 10 cases, 6 cases were
       orally given AZT and 4 cases ddI. Bone marrow examination during
       neutropenic episode revealed decreased neutrophil counts and disturbed
       maturation in the bone marrow. Following the administration of rG-CSF,
       clinical symptoms were alleviated with increased neutrophils in 9 of 10
       patients. In the pharmacokinetic examination performed after
       administration of rG-CSF, the mean t1/2 was slightly longer than in
       healthy volunteers. Decreased neutrophil H2O2 production and impaired
       phagocytosis were also noted in HIV positive hemophiliacs with
       neutropenia. DISCUSSION: The results suggest that decreased (or
       inadequate) production or release of G-CSF may play a role in the
       pathogenesis of neutropenia in HIV positive hemophiliacs.
 DE    Biological Markers/BLOOD  Granulocyte-Macrophage Colony-Stimulating
       Factor/*BLOOD/  PHARMACOKINETICS  Hemophilia/*BLOOD/COMPLICATIONS  Human
       HIV Seropositivity/*BLOOD  Neutropenia/*BLOOD/DIAGNOSIS/ETIOLOGY
       Recombinant Proteins/BLOOD/PHARMACOKINETICS  Sensitivity and Specificity
       MEETING ABSTRACT

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