Document 1199
 DOCN  M94A1199
 TI    Influence of intravenous therapy with normal human immunoglobulin on
       haemostasis system in HIV-infected patients.
 DT    9412
 AU    Kravchenko AV; Polyakova AM; Yurin OG; Astrina OS; Serebrovskaya LV;
       Pokrovsky VV; Russian AIDS Centre, Moscow.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):186 (abstract no. PB0759). Unique
       Identifier : AIDSLINE ICA10/94371376
 AB    OBJECTIVE: To define the effect of normal human immunoglobulin (Ig)
       therapy on the haemostasis system in the HIV-infected. METHODS:
       Calculation of thrombocytes, their aggregation (ADP--2 x 10(-5)), their
       endo-exocytosis; electrocoagulogramm; APTT; concentration of fibrinogen;
       These tests were done before, 7-10 days and 1-3 months after Ig therapy.
       RESULTS: 21 HIV-infected adults: AIDS--6 patients, ARC--15 besides their
       basic therapy (AZT, antifungal, antibacterial drugs) also received 5% Ig
       (products of N. Novgorod, Russia, price 1.25 g--5$) 50.0 ml per day over
       2 days. Middle count of CD4--163.0 +/- 24.3 x 10(6)/l; CD8--779.6 +/-
       73.5 x 10(6)/l; concentration of IgG--32.1 +/- 2.2 g/l; IgM--3.55 +/-
       0.46 g/l; IgA--4.64 +/- 0.51 g/l; CIC--290.4 +/- 33.6 opt.un. Before Ig
       therapy: middle count of platelets (plt.)--106.2 +/- 7.1 x 10(9)/l;
       their aggregation--66.9 +/- 8.8% (control--100.0 +/- 5.3%, p < 0.01):
       1-st group (10 pts.)--95.8 +/- 8.7% and 2-nd gr. (11 pts.)--33.2 +/-
       8.3%; their exocytosis--8.38 +/- 1.42% (control--16.3 +/- 1.0%, p <
       0.01); APTT--93.2 +/- 7.8 sec. (control--43.5 +/- 4.0 sec., p < 0.01);
       fibrinogen--1.77 +/- 0.16 g/l (control--2.59 +/- 0.11 g/l, p < 0.01).
       After 7-10 days: middle count of plt.--173.9 +/- 14.4 x 10(9)/l (p <
       0.01 with before Ig therapy); their aggregation--69.0 +/- 6.5%: 1-st
       gr.--90.9 +/- 9.9%, 2-nd gr.--58.0 +/- 16.5%; APTT, concentration of
       fibrinogen, exocytosis of plt. and parameters of electrocoagulogramm
       didn't change reliable. After 1-3 months: middle count of plt.--205.5
       +/- 30.2 x 10(9)/l (p < 0.01 with before Ig therapy); their
       aggregation--66.3 +/- 9.1%; the parameters of plasma part of haemostasis
       and the exocytosis of plt. didn't change. CONCLUSIONS: The therapy of
       Russian Ig, wich is very cheap, given besides basic therapy, has
       beneficial effects both on blood plt. count and their aggregation
       exclusively in the HIV-infected pts., who had decreasing it. This
       positive effect is probably due to decrease of autoimmune reactions that
       occur during this disease. Ig therapy didn't influence on exocytose of
       plt. and plasma part of haemostasis.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD/IMMUNOLOGY/*THERAPY  Adult
       AIDS-Related Complex/*BLOOD/IMMUNOLOGY/*THERAPY  Exocytosis
       Fibrinogen/ANALYSIS  Follow-Up Studies  *Hemostasis  Human  IgA/BLOOD
       IgG/BLOOD  Immunoglobulins, Intravenous/*THERAPEUTIC USE  Partial
       Thromboplastin Time  Platelet Aggregation  Platelet Count  Time Factors
       Zidovudine/THERAPEUTIC USE  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).