Document 2297
 DOCN  M94A2297
 TI    HIV-1, HTLV-1, and tuberculosis among intravenous drug users in Rio de
       Janeiro, Brazil.
 DT    9412
 AU    Kritski A; Carvalho AC; Schechter M; Vieira MA; Oliveira J;
       Werneck-Barroso E; Ferreira O; Novor P; Hearst N; Nucleo de Pesquisa em
       Tuberculose, Servico de Pneumologia do; Hospital Univ. Clementino Fraga
       Filho, Universidade Federal do; Rio de Janeiro, Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):336 (abstract no. PC0278). Unique
       Identifier : AIDSLINE ICA10/94370278
 AB    OBJECTIVE: To evaluate the association between Tuberculosis infection
       and TB disease and HIV-1 and/or HTLV-1 infection among IVDUs who
       attended a Drug Treatment Center (NEPAD/UFRJ) in Brazil. METHODS: From
       July, 1991 to October, 1992, 80 IVDUs (68 male) were consecutively
       referred to Chest Service by NEPAD/UFRJ. After written consent, they
       were examined, asked to answer a questionnaire, and tested for HIV and
       HTLV-1 infection. RESULTS: The mean age was 28.8 SD +/- 6.4 yrs. HIV-1
       infection and HTLV-1 occurred in 25 (31.2%) and 22 (27.5%) IVDUs,
       respectively; 12 (15.0%) were infected by both. In the last 3 years, 70
       (93.3%) of IVDUs have used cocaine; 62 (82.6%) marijuana. Twenty-one
       (26.3%) were homosexual men and 4 (5.3%) reported prostitution in the
       last 6 months. Among HIV-1 seronegative IVDUs, a positive PPD skin test
       (> 10mm) was observed in 69.3% (10/46); among HIV-1 seropositives, 40%
       (8/20) (using > 5mm). Fourteen (17.5%) IVDUs had respiratory symptoms; 3
       (3.7%) had culture-proven TB (all with HIV-1 and 2 with HTLV-1
       infection). Two (2.5%) mentioned anti-TB treatment in the past, and 11
       (13.7%) reported TB in the last 3 years within the family. The
       occurrence of positive PPD skin test or TB disease was not associated
       with the following variables: race, sex, schooling less than 4 years,
       family monthly income less than US $1,000, alcoholism (using CAGE test),
       severity of alcoholism (using SAAD test) and duration of the use of
       drugs. But significant association was found between HIV-1, HTLV-1/2
       infection, and the occurrence of negative PPD skin test, TB disease and
       severity of alcoholism. CONCLUSIONS: In Rio de Janeiro, the high rate of
       HIV-1, HTLV-1 infection, and TB infection among IVDUs highlights the
       possible burden of this association. This information must be taken into
       account when these individuals are treated in any health care setting,
       related or not to drug addiction.
 DE    Adult  AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY/TRANSMISSION
       Brazil/EPIDEMIOLOGY  *Developing Countries  Female  Human  HIV
       Infections/*EPIDEMIOLOGY/TRANSMISSION  *HIV-1  *HTLV-I  HTLV-I
       Infections/*EPIDEMIOLOGY/TRANSMISSION  Male  Mass Screening  Risk
       Factors  Substance Abuse Treatment Centers  Substance Abuse,
       Intravenous/COMPLICATIONS/*EPIDEMIOLOGY  Tuberculosis,
       Pulmonary/*EPIDEMIOLOGY/TRANSMISSION  Urban Population/*STATISTICS &
       NUMER DATA  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).