Document 2307
 DOCN  M94A2307
 TI    AIDS among IDU's: when a needle can be a 'vector'.
 DT    9412
 AU    Burattini M; Massad E; Carvalho HB; Mesquita F; Bueno RC; Paes GL;
       School of Medicine, University of Sao Paulo, Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):334 (abstract no. PC0272). Unique
       Identifier : AIDSLINE ICA10/94370268
 AB    Adapting the Macdonald's theory for vector-borne infections, we
       estimated the Basic Reproduction Number, RO, of HIV among IVD users.
       This was done by applying a structured questionnaire to 68 heavy users
       of injected cocaine from the city of Santos, Sao Paulo, Brazil. The
       observed seroprevalence of this group was 64%. Macdonald defined RO in
       terms of entomological parameters, some of which were re-defined for the
       injection apparatus. So, the average number of 'bites' inflicted by a
       needle per unit of time, a, the proportion of sharing needles among this
       group, p, the density of needles as related to the human population, m,
       the probability of a needle to get the infection after being used by a
       seropositive individual, alpha, the average period of time a positive
       individual remains in the IVDU community, 1/r, and the average period of
       time a needle remains infective, 1/(alpha + mu), were related to RO, by:
       TABULAR DATA, SEE ABSTRACT VOLUME. where Nh is the size of the human
       population and X(O) is the initial proportion of seronegatives. Our data
       resulted in a value of RO = 35.7.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/*TRANSMISSION  Animal
       Brazil/EPIDEMIOLOGY  *Cocaine  *Disease Vectors  Human  HIV
       Seropositivity/EPIDEMIOLOGY/TRANSMISSION  Models, Statistical  Needle
       Sharing/*STATISTICS & NUMER DATA  Probability  Risk  Substance Abuse,
       Intravenous/*COMPLICATIONS/EPIDEMIOLOGY  Substance
       Dependence/*COMPLICATIONS/EPIDEMIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).