Document 2338
 DOCN  M94A2338
 TI    Differential survival of AIDS patients according to the 1987 and the
       1993 CDC case definitions.
 DT    9412
 AU    Vella S; Chiesi A; Floridia M; Giuliano M; Volpi A; Dally LG; Binkin N;
       Istituto Superiore di Sanita Rome, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):327 (abstract no. PC0240). Unique
       Identifier : AIDSLINE ICA10/94370237
 AB    OBJECTIVE. To evaluate the impact of the 1993 CDC HIV classification
       system versus the 1987 definition on the number of cases and on survival
       of AIDS patients through the retrospective analysis of data from a
       prospective cohort study of patients treated with zidovudine. A total of
       3515 patients enrolled in the National Registry of zidovudine-treated
       patients between July 1987 and December 1991 were analysed. RESULTS. We
       compared numbers and survival probability estimates (using the
       Kaplan-Meier method) for patients satisfying the 1993 CDC case
       definition compared to patients fulfilling the 1987 CDC classification.
       According to the new classification system the number of AIDS cases in
       the study population would increase by 188%. While the median survival
       of patients meeting the 1987 definition was 24 months, at the end of 57
       months 47% of patients meeting the 1993 definition were still alive.
       Among the patients meeting the laboratory criteria for AIDS diagnosis
       using the new definition (CD4+ count < 200), the presence of an
       AIDS-defining illness was a strong independent predictor of death.
       CONCLUSIONS. The application of the new definition results in a
       considerable increase in the number of cases. Survival of patients
       classified according to the 1993 definition is much longer than for
       those classified with the 1987 definition. Clinical status plays a major
       role in predicting survival outcome among patients whose CD4+ levels
       meet the new case definition.
 DE    Acquired Immunodeficiency Syndrome/CLASSIFICATION/DRUG THERAPY/
       *MORTALITY  Cohort Studies  Human  HIV Infections/CLASSIFICATION/DRUG
       THERAPY/*MORTALITY  Italy/EPIDEMIOLOGY  Leukocyte Count  Prospective
       Studies  Registries/STATISTICS & NUMER DATA  Retrospective Studies
       Survival Rate  T4 Lymphocytes/IMMUNOLOGY  Zidovudine/THERAPEUTIC USE
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).