Document 2354
 DOCN  M94A2354
 TI    Possible lethal outcome of primary HIV-infection in children of
       nosocomial focus.
 DT    9412
 AU    Sauhat S; Pokrovsky VV; Savkova Z; Tormozova N; Prokopenkova S; Orlov N;
       Zhuravliova I; SIU Biopreparat, Rostov-on-Don, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):323 (abstract no. PC0225). Unique
       Identifier : AIDSLINE ICA10/94370221
 AB    OBJECTIVE: To make clear the reasons of elevated lethality caused by
       sepsis, among the children treated in 1988-1989 years at the same
       hospital department with another children then becoming seropositive for
       HIV as a result of intrahospital infection. METHODS: Risk of
       HIV-infection and clinical disease symptoms were evaluated by special
       computer program in 14 infants. 2-10 months old, preferably with
       diarrhea diagnosis (9 persons), who were dead at infectional department
       of Shahty town hospital in the period of intrahospital spread of
       HIV-infection, but were not tested for HIV-antibodies. RESULTS: It was
       shown, that died children who were at hospital at the same time with
       proposed sources of HIV, had got intravenous injections and other
       invasive manipulations respectively 1,9 and 1.2 times more. then
       HIF-infected ones, and also in 6 and 3 times respectively more than
       children appeared to be noninfected. I.e., died children were exposed of
       high risk of HIV-infectioning. Possible participating of 3 children
       before lethal outcome in epidemic process as the sources of causative
       agent was estimated for 9 children being then revealed as HIV-infected
       ones. At 2-12 weeks from the beginning of primary hospitalization
       clinical picture was accompanied by enhancement of fever (in 13
       children), by intensification of diarrhea (in 14), hepatosplenomegaly
       (in 14). At blood laboratory tests leuco- and erythropenia were founded
       in 14 children, thrombocytopenia--in 7 ones. Fatal outcome was happened
       2-12 weeks after indicated symptoms appearence, in spite of
       antibacterial and detoxicative therapy. DISCUSSION AND CONCLUSIONS:
       Lethal outcomes of children who was undergoed HIV-infection risk in the
       nosocomial focus, can be caused by HIV-infection. though there is no
       data about lethal outcomes of primary stage of HIV-infection in
       literature. The death of these children was explaned by small age and
       HIV-infection addition to the basic disease being the reason of
       hospitalisation.
 DE    AIDS-Related Opportunistic Infections/*MORTALITY/TRANSMISSION  Cross
       Infection/*MORTALITY/TRANSMISSION  Diarrhea, Infantile/MORTALITY
       Equipment Contamination  Female  Hospital Mortality  Human  HIV
       Infections/*MORTALITY/TRANSMISSION  HIV
       Seropositivity/MORTALITY/TRANSMISSION  Infant  Male  Risk Factors
       Russia/EPIDEMIOLOGY  Survival Rate  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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