Document 2355
 DOCN  M94A2355
 TI    HLA type and susceptibility to HIV infection and AIDS among children in
       Catalonia.
 DT    9412
 AU    Just JJ; Casabona J; King MC; Institut de Recerca, Hospital de Sta Creu
       i St Pau, Barcelona,; Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):323 (abstract no. PC0224). Unique
       Identifier : AIDSLINE ICA10/94370220
 AB    OBJECTIVE: Among children born to HIV-infected mothers, not all will
       become infected, and among those that do become infected, the course of
       disease is variable. The rate of vertical HIV transmission in Catalonia
       is estimated to be 19%. Among HIV-infected children, the prognosis is
       very poor with 15% dying within the first year of life. By 3 years of
       age, the mortality rate is greater than 50%. Still, many children
       survive more than 6 years. We have begun a study to determine if HLA
       genotype of perinatally-exposed children influences their chances of
       either becoming infected or the subsequent course of AIDS progression.
       METHODS: Blood samples and clinical information from
       perinatally--exposed children are being collected from four hospitals in
       and around Barcelona. DNA is extracted, amplified by PCR and hybridized
       with SSO's to determine genotype at class II HLA DPB1, DQB1, DQA1 and
       DRB1. RESULTS: To date, 60 children have been sampled: 47 infected, 8
       seroreverter and 5 indeterminate. We anticipate collecting at least 40
       more infected and 50-100 more seroreverters within the next few months.
       The infected children range in age from 5 months to 9 years. Fast and
       slow progression groups will be determined using CD4 counts and age and
       correlated with presence of specific HLA genotypes. In addition,
       survival analyses will be performed for children with and without
       specific HLA types. Finally, infected and seroreverter children will be
       compared to assess HLA associations with serostatus. Results from these
       analyses will be presented. CONCLUSION: Many studies report consistent
       associations between HLA and HIV/AIDS among adults. It will be
       worthwhile to know if these previously reported associations are found
       among children as well.
 DE    Acquired Immunodeficiency Syndrome/GENETICS/MORTALITY/  *TRANSMISSION
       Child, Preschool  Female  Follow-Up Studies  Genotype  Human  HIV
       Infections/GENETICS/MORTALITY/*TRANSMISSION  HLA Antigens/*GENETICS
       Infant  Infant, Newborn  Leukocyte Count  Pregnancy  Spain/EPIDEMIOLOGY
       Survival Rate  T4 Lymphocytes/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).