Document 2363
 DOCN  M94A2363
 TI    Interleukin 6 and AIDS Kaposi's sarcoma.
 DT    9412
 AU    Dourado I; Detels R; Martinez-Maza O; UCLA School of Public Health.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):321 (abstract no. PC0213). Unique
       Identifier : AIDSLINE ICA10/94370212
 AB    Since the beginning of the AIDS epidemic, a large research activity has
       focused on the etiology of Kaposi's sarcoma (KS) among HIV infected
       individuals. There are several hypothesized risk factors for AIDS-KS.
       However, there is not enough evidence supporting the existing
       hypotheses. Recently, a number of studies have confirmed that HIV or HIV
       encoded products can interact with human cells to produce immune
       cytokines. One of these cytokines is known as interleukin 6 (IL-6). In
       vitro observations have indicated that AIDS-KS cells can produce and
       respond to significant levels of IL-6. In addition, preliminary data
       suggest that IL-6 may be elevated among HIV infected individuals that
       subsequently develop AIDS-KS. The objective of this study was to
       investigate if elevated levels of IL-6 are associated with an increased
       incidence of AIDS-KS compared to other AIDS-defining illnesses such as
       opportunistic infections (OIS). The specimens were frozen sera from the
       participants of the Multicenter AIDS Cohort Study (MACS). IL-6 was
       measured with an ELISA assay at 6 months prior to the AIDS diagnosis for
       73 cases (AIDS-KS) and 152 controls (OIS). We found that IL-6 levels
       were more prevalent among OIS than among AIDS-KS: crude odds ratio (OR)
       was 0.4 (95% CI 0.2-0.9). Models of multivariate logistic regression
       were used to study potential confounders. Sexual behavior variables did
       not seem to be confounders of the association between IL-6 and AIDS-KS.
       The higher prevalence of IL-6 among controls could be explained by the
       association of higher levels of IL-6 with lower levels of CD4 T cell
       number. IL-6 might be a marker of immunedysfunction among HIV infected
       individuals.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY/
       METABOLISM  AIDS-Related Opportunistic Infections/METABOLISM  Cohort
       Studies  Enzyme-Linked Immunosorbent Assay  Human
       Interleukin-6/*BIOSYNTHESIS  Sarcoma, Kaposi's/ETIOLOGY/*METABOLISM
       MEETING ABSTRACT  MULTICENTER STUDY

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