Document 2377
 DOCN  M94A2377
 TI    Natural history of HIV-1 infection among injecting drug users.
 DT    9412
 AU    Siddiqui N; Brown LS; Meyer TJ; Addiction Research and Treatment
       Corporation, Brooklyn, NY 11201.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):318 (abstract no. PC0202). Unique
       Identifier : AIDSLINE ICA10/94370198
 AB    OBJECTIVE: To evaluate the natural history of HIV-1 infection among
       injecting drug users (IDU) attending a methadone maintenance program in
       New York City (NYC). METHODS: Between December 1988 and August 1991, 350
       HIV-1 infected IDU were enrolled in a natural history study. Baseline
       and follow-up assessments including information regarding
       sociodemographic characteristics, HIV related symptomatology, drug use,
       sexual practices, and laboratory studies. RESULTS: The study sample was
       nearly two-thirds male, predominantly African American and Latino, and
       had a mean age of 37 years. The Kaplan-Meier plot showed that subjects
       with a baseline CD4 count of less than 200 had shorter survival times (p
       < .001). Race/ethnicity was not related to survival. Married
       participants had longer survival times (p < .05). Baseline CD8 levels
       independently predicted survival (cut point 300). Higher scores on
       HIV-disease-related symptoms scale were associated with shorter survival
       time (p < .001). Decreasing levels of CD4 cells and increasing levels of
       Beta-2-macroglobulin over time also predicted survival, even when
       adjusted for baseline CD4 levels (p < .05). DISCUSSION: This report
       describes natural history of HIV-1 infection among NYC IDU in a
       non-hospital study setting which may provide a more realistic assessment
       than controlled clinical trials. Supported by NIDA.
 DE    Adult  Female  Human  HIV Infections/*COMPLICATIONS  *HIV-1  Male
       Substance Abuse, Intravenous/*COMPLICATIONS  Support, U.S. Gov't, P.H.S.
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).