Document 2378
 DOCN  M94A2378
 TI    Determinants of HIV disease progression among homosexual men in the
       tricontinental seroconverter study.
 DT    9412
 AU    Veugelers PJ; Page KA; Tindall B; Schechter MT; Moss AR; Coutinho RA;
       van Griensven GJ; Municipal Health Service, Amsterdam, The Netherlands.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):318 (abstract no. PC0201). Unique
       Identifier : AIDSLINE ICA10/94370197
 AB    OBJECTIVE: To evaluate progression from HIV seroconversion (SC) to AIDS
       and death in relation to demographic, clinical and behavioral factors.
       METHODS: Data of 403 homosexual men with documented dates of SC
       originating from five cohorts were merged in order to study the effect
       of co- and risk factors of disease progression. Cox proportional
       relative hazards were estimated for factors possibly related with time
       from SC to AIDS and death. RESULTS: 114 men developed AIDS and 67 died.
       Median time from SC to AIDS and death was 8.4 and 8.9 years. HIV disease
       progression and AIDS diagnoses patterns did not differ with regard to
       geographic location. Seroconverting after 1983 was significantly related
       with faster progression to AIDS and death (Relative Hazards SC to death:
       < or = 1983 1; 1984 2, 1985 2.4; 1986 2.4). Older age was significantly
       related with faster progression to death only (Relative Hazard 1.5 per
       10 years). Use of PCP prophylaxis reduced disease progression, although
       the relation with time to AIDS was not statistically significant. No
       statistically significant associations were found between progression in
       HIV disease and STD's, number of sexual partners, use of zidovudine,
       alcohol, tobacco and recreational drugs. DISCUSSION: Our observations
       suggest that later date of SC is related with faster disease
       progression. Time from SC to AIDS and death in our study is shorter than
       observed in other studies. These differences might be the result of the
       relation between disease progression and year of seroconversion, since
       the latter studies started earlier and included men with earlier dates
       of SC. Relations with age and PCP prophylaxis concur with findings in
       other observational studies.
 DE    Acquired Immunodeficiency Syndrome/MORTALITY/*PATHOLOGY  Age Factors
       AIDS-Related Opportunistic Infections/PREVENTION & CONTROL
       *Homosexuality  Human  *HIV Seropositivity  Male  Pneumonia,
       Pneumocystis carinii/PREVENTION & CONTROL  Risk Factors  Time Factors
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).