Document 2379
 DOCN  M94A2379
 TI    Activated CD8+ lymphocytes in HIV infection.
 DT    9412
 AU    De Martinis M; D'Ostilio A; Ginaldi L; Profeta FV; Quaglino D; Clinica
       Medica University of L'Aquila, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):318 (abstract no. PC0203). Unique
       Identifier : AIDSLINE ICA10/94370196
 AB    There are evidence that HIV disease progression is associated with
       elevated numbers of CD8+ cells that bear the phenotypic surface markers
       of activated cells (AIDS 1992; 6:793, Clin. Exp. Immunol. 1992; 90:376).
       This activation of the Immune System may play a role in maintaining an
       adequate response to lessen the progression of infection. 94
       seropositive drug addicts were stratified into four groups based on
       clinical data: 10 Asymptomatic, 26 LAS, 33 ARC and 25 AIDS. Lymphocyte
       subsets and the expression of HLA-DR on CD8+ cells from peripheral blood
       samples were examined by dual-color flow-cytometry using standardized
       lysed blood method. As control groups were enrolled 22 seronegative drug
       addicts and 22 healthy subjects. CD8+HLA-DR+ lymphocytes were
       significantly increased in the HIV-1+ group respect to control groups:
       mean values HIV + 6.38 + 4.6, HIV-drug addicts 1.13 + 1.7 and healthy
       1.0 + 0.7 p < 0.001). The proportion of CD8+HLA-DR+ cells increased
       progressively with each more advanced HIV clinical stage (from 6% in
       Asymptomatics to 8.6% in AIDS). There is a significant inverse
       correlation between CD8+HLA-DR and CD4+ cell counts in the Asymptomatic,
       LAS and ARC group, while the correlation between the levels of
       lymphocyte subsets seem to become direct in AIDS patients. Activated
       CD8+ cells may represent a specific immune response to the virus,
       contributing to the maintenance of asymptomatic state as long as
       possible. The progressive damage of the Immune System can explain why
       CD8+HLA-DR+ cells decrease at the end of the natural history of the
       disease, when infection overcome.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Antigens, CD8/*ANALYSIS
       AIDS-Related Complex/IMMUNOLOGY  Flow Cytometry  Human  HIV
       Infections/*IMMUNOLOGY  *HIV-1  HLA-DR Antigens/ANALYSIS  Leukocyte
       Count  *T-Lymphocyte Subsets  MEETING ABSTRACT

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