Document 2397
 DOCN  M94A2397
 TI    HIV infection in women: a eight year longitudinal observational study.
 DT    9412
 AU    Laynez F; Diez F; Collado A; Yelamos F; Fernandez P; Hospital
       Torrecardenas, Almeria, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):313 (abstract no. PC0184). Unique
       Identifier : AIDSLINE ICA10/94370178
 AB    OBJECTIVE: To study the epidemiology, clinical characteristics and
       evolution in a cohort of HIV-infected women in the South of Spain.
       METHODS: A observational study of 242 HIV+ women from their first study
       to the last clinical control or death, between 1/86-12/93. Kaplan Meier
       and logrank tests were used for survival analysis. RESULTS: Median age
       was 30 years. HIV risks included IDU in 64%, heterosexual contact in
       32%, transfusion in 3% and unknown in 1%. The proportion of
       heterosexually infected patients showed an increase from 16% in
       1986-1987 to 50% in 1992-1993. Only 143 patients (59%) are periodically
       controlled. At entry 31 (29%) had more than 500 CD4/mm, 45 (42%O had
       between 200-500 CD4/mm, 17 (16%) between 50-200 CD4/mm and 13 (12%) less
       than 50 CD4/mm. Of the 33 (23%) women with AIDS, the inicial AIDS
       defining conditions were Candida esophagitis (8), PCP (8), caquexia (6),
       disseminated tuberculosis (5), cerebral toxoplasmosis (3) and CMV
       iotinitis, Kaposi sarcoma and lymphoma (1u each). 16 (11%) women have
       died. The median survival time was 5.5 years from the first clinical
       control and 20 months from AIDS diagnosis. CD4 count at entry was the
       most powerful marker of survival. No other survival differences were
       detected based on risk factor or AIDS-defining diagnosis. Overall
       survival was similar to that of men. CONCLUSIONS: 1) In this area, IDU
       is the first HIV-risk behavior in women and heterosexual transmission is
       increasing very quickly. 2) Only 59% of HIV-infected women have periodic
       follow up. 3) CD4 count at entry is the stronger marker of evolution.
 DE    Acquired Immunodeficiency Syndrome/DIAGNOSIS/MORTALITY  Adult
       AIDS-Related Opportunistic Infections/EPIDEMIOLOGY  Cohort Studies
       Female  Human  *HIV Infections/DIAGNOSIS/EPIDEMIOLOGY  HIV
       Seropositivity  Risk Factors  Sex Behavior  Spain/EPIDEMIOLOGY  Survival
       Rate  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).