Document 2401
 DOCN  M94A2401
 TI    Nutritional abnormalities in HIV-1 infected female drug users (IDUs).
 DT    9412
 AU    Baum M; Carcamo C; Quesada J; Page BJ; Fletcher MA; Shor-Posner G;
       Department of Epidemiology, University of Miami School of; Medicine, FL.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):312 (abstract no. PC0178). Unique
       Identifier : AIDSLINE ICA10/94370174
 AB    OBJECTIVE: To characterize nutritional status, which may be an important
       cofactor in determining the course of HIV-1 disease progression, in
       HIV-1 seropositive and seronegative female IDUs. METHODS: Standard
       methodology was used to determine plasma zinc, prealbumin and vitamins
       A, E, B6 and B12 in 29 females. Ten were HIV-1+ with a mean CD4 cell
       count of 390 +/- 190 cumm, and 19 were HIV-1 seronegative female control
       IDUs (mean CD4 cell count of 1077 +/- 305 cumm). RESULTS: Eighty percent
       of the HIV-1 infected females and 74% of the seronegative controls
       exhibited at least one nutritional biochemical deficiency. Whereas
       inadequate vitamin B12 status (< 240 pg/ml) was demonstrated in 40% of
       the seropositive females, none of the seronegative women exhibited
       inadequate vitamin B12 levels. In addition, a higher proportion (80%) of
       low plasma zinc levels (< 0.85 mg/ml) was observed in the seropositive,
       as compared to 47% of the seronegatives with marginal/deficient levels
       of zinc. The mean values for prealbumin were similar and within the
       normal range for the HIV-1 seropositive and seronegative females.
       Biochemical deficiencies of vitamin A (< or = 0.3 mg/ml) and vitamin E
       (< or = 5 mg/ml) were particularly widespread, occurring in 60% of the
       seropositive and and 58% of the seronegative IDUs. DISCUSSION AND
       CONCLUSIONS: Nutrient abnormalities, which are prevalent in seropositive
       and seronegative female IDUs, may reflect poor dietary intake and be
       related to drug-nutrient interactions. Low levels of vitamin B12 and
       zinc appear to be affected by HIV-1 status, and may influence HIV-1
       disease progression and HIV-1 viral activity.
 DE    Female  Human  HIV Infections/*COMPLICATIONS  HIV Seropositivity  *HIV-1
       Nutrition Disorders/*COMPLICATIONS/DIAGNOSIS  Prealbumin/ANALYSIS
       Substance Abuse, Intravenous/*COMPLICATIONS  Vitamins/BLOOD  Zinc/BLOOD
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).