Document 2408
 DOCN  M94A2408
 TI    Natural history of vertically acquired HIV infection.
 DT    9412
 AU    Giaquinto C; De Rossi A; Pagliaro A; Cozzani S; Ruga E; Mazza A;
       Giacomelli A; Tessarotto L; Oletto S; Dep. of Pediatrics, Univ. of
       Padova, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):310 (abstract no. PC0170). Unique
       Identifier : AIDSLINE ICA10/94370167
 AB    OBJECTIVES: To study the natural history of pediatric HIV infection.
       METHODS: All children born to seropositive mothers were identified and
       followed from birth clinically, immunologically and virologically (PCR
       and virus culture) every 4-6 weeks in the first 6 months, and 6 monthly
       there after. Children were defined as infected if symptomatic or if the
       virus was identified in the blood on 2 or more occasions at least apart.
       RESULTS: By January 1994, 246 children have been enrolled; 173 since
       birth and 73 after birth, 78% were born to drug user mothers, 22% to
       mothers with seropositive partners. The mean length of follow up of
       patients enrolled at birth was 39 months. At 6 months children followed
       up from birth were classified as follows: 28 infected, 133 uninfected,
       12 indeterminate. One child although seronegative had evidence of viral
       genome on repeated virus culture and PCR. The transmission rate
       calculated at 6 months is 16% (C.I. 10.9-21.7) and do not differ fron
       that reported by European collaborative Study. Children followed up from
       birth have AIDS (CDC classification), among these group 10 presented
       encephalopathy (American Academy of Neurology AIDS Task Force). Several
       virological factors (viral phenotypes, viral burden etc.) were
       prognostically correlated with the outcome of infection.
 DE    Female  Follow-Up Studies  Human  HIV Infections/DIAGNOSIS/*TRANSMISSION
       HIV Seropositivity  Infant  Infant, Newborn  Pregnancy  *Pregnancy
       Complications, Infectious  MEETING ABSTRACT

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