Document 2416
 DOCN  M94A2416
 TI    Investigating of HIV-1 transmission from mother to child.
 DT    9412
 AU    Yukiko T; Sadamasu K; Mori K; Inaba M; Sekine H; Hirokawa J; Miyazawa Y;
       Tokyo Metropolian Research Laboratory of Public Health, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):309 (abstract no. PC0166). Unique
       Identifier : AIDSLINE ICA10/94370159
 AB    OBJECTIVE: To investigate the HIV-1 transmission from mother to child,
       we tried to detect the HIV-1 associated markers. METHODS: Samples from 4
       HIV-1 seropositive pregnant mothers, 2 children born by cesareans and 2
       fetuses from therapeutic abortion were assayed. We tried to detect HIV-1
       antibody, p24 antigen and proviral genome and isolate HIV-1 from
       peripheral blood, cord blood, amniotic fluid, placenta, tissues of
       fetuses using western blot, antigen captured ELISA, PCR and tissue
       culture, respectively. RESULTS: HIV-1 proviral genome were detected in
       peripheral blood from 4 mothers but we could neither detect p24 antigen
       nor isolate HIV-1. None of HIV-1 markers except antibody has been
       detected in the samples from their children and fetuses. DISCUSSION AND
       CONCLUSIONS: No case of HIV-1 transmission from mother to child has been
       confirmed. It was suggested that PCR was more useful and effective
       method than the other ones to investigate HIV-1 maternal transmission.
       We are going to follow up their children and continue the investigation.
 DE    AIDS Serodiagnosis  Female  Human  HIV
       Infections/DIAGNOSIS/*TRANSMISSION  HIV Seropositivity  *HIV-1/ISOLATION
       & PURIF  Infant, Newborn  Pregnancy  *Pregnancy Complications,
       Infectious/DIAGNOSIS  MEETING ABSTRACT

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