Document 2422
 DOCN  M94A2422
 TI    Perinatal transmission among women seroconverting during pregnancy,
       Bangkok.
 DT    9412
 AU    Shaffer N; Roongpisuthipong A; Siriwasin W; Wasi C; Kaewchaiyo G;
       Chearskul S; Chotpitayasunondh T; HIV/AIDS Collaboration, Bangkok,
       Thailand.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):308 (abstract no. PC0163). Unique
       Identifier : AIDSLINE ICA10/94370153
 AB    OBJECTIVES: Newly infected women may be at highest risk of vertical
       transmission due to transient high circulating viral load. This study
       aims to determine the immunologic and virologic characteristics and risk
       of vertical transmission for pregnant women who seroconvert during
       pregnancy. METHODS: At 2 large hospitals with routine HIV counseling and
       testing at first and late 3rd trimester antenatal visits, pregnant women
       documented to have seroconverted during pregnancy are enrolled as a
       special subgroup in a prospective mother-child perinatal transmission
       study. Seroconverting pregnant women (SC) were compared with those
       testing HIV positive at enrollment (POS). RESULTS: The background
       antenatal HIV seroprevalence in 1993 was 2%. From Nov 1992 through Jan
       1994, 313 HIV infected women have been enrolled during pregnancy,
       including 11 SC. Available immunologic data (% and median values) are:
       TABULAR DATA, SEE ABSTRACT VOLUME. The background vertical transmission
       rate in the cohort is 26%. Thus far, 1/6 (17%) of SC has transmitted
       infection to her infant. Enrollment and laboratory studies are
       continuing. CONCLUSIONS: On initial testing, women identified to
       seroconvert during pregnancy appear to have similar or lower immune
       markers than seropositive pregnant women entering antenatal care.
       Further characterization of the immune profile, viral load, and risk of
       vertical transmission in this group may lead to a better understanding
       of the mechanisms of vertical transmission.
 DE    CD4-CD8 Ratio  Female  Human  HIV
       Infections/IMMUNOLOGY/MICROBIOLOGY/*TRANSMISSION  *HIV Seropositivity
       Infant, Newborn  Pregnancy  *Pregnancy Complications,
       Infectious/IMMUNOLOGY/MICROBIOLOGY  Risk Factors  T-Lymphocyte Subsets
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).