Document 2429
 DOCN  M94A2429
 TI    Risk of HIV-related symptoms in 40 sets of twins: a population-based
       analysis.
 DT    9412
 AU    Fanning T; Krasinski K; Chiarella J; Turner BJ; New York State (NYS)
       Dept. of Social Services, Albany.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):306 (abstract no. PC0153). Unique
       Identifier : AIDSLINE ICA10/94370146
 AB    OBJECTIVE: To determine risk factors for HIV-related symptoms among
       twins. METHODS: A longitudinal claims data base for NYS
       Medicaid-enrolled, HIV-infected parturients in 1985-90 was reviewed and
       those delivering twins were analyzed. For twins with matched vital
       statistics, we examined longitudinal histories in Medicaid claims files
       for an AIDS-defining infection and/or the diagnosis of HIV at > 15 mos.
       (likely HIV) or > or = serious infection (e.g., pneumonia) and HIV at <
       or = 15 mos. (suspect HIV). Other twins were considered HIV unlikely.
       RESULTS: Of 2,823 deliveries to 2,349 women in 1985-90, we identified 60
       sets of twins, of whom 40 had vital statistics data. Mean follow-up was
       36 mos. (s.d. 20). Overall 7/40 sets (17.5%) had HIV (likely or suspect)
       with 5 concordant and 2 discordant (P = .4795 for discordance by
       McNemar's test). Of discordant sets, one case each was first-born and
       second-born and one set was delivered by C-section. Of 18 C-sections, 5
       sets (28%) had HIV compared to 2 of 20 (10%) vaginal deliveries (P = .13
       by Fisher's Exact test). One woman with AIDS had a set with both twins
       dying of AIDS infections but the twins of the other 10 women with AIDS
       were HIV unlikely. Five HIV sets were born to 23 drug users (22%)
       compared to 2/17 sets (12%) of non-drug users. Of 28 women with prenatal
       care data, 8 had adequate care and 1/8 sets had HIV (12%), compared to
       5/20 sets of 20 women with inadequate care (25%). No women used AZT in
       pregnancy. CONCLUSION: HIV discordance was uncommon and bidirectional in
       these population-based data. Indications for C-section were not
       available but no protective effect was observed. Although HIV infections
       appeared more frequent among infants of women using drugs or infants of
       women with little prenatal care, significance was not achieved in these
       data.
 DE    *Diseases in Twins  Female  Follow-Up Studies  Human  HIV
       Infections/CONGENITAL/DRUG THERAPY/*TRANSMISSION  Infant, Newborn
       Longitudinal Studies  Pregnancy  *Pregnancy Complications,
       Infectious/DRUG THERAPY  Risk Factors  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).