Document 2506
 DOCN  M94A2506
 TI    HIV-1 serotypes in Thailand during 1985-1994.
 DT    9412
 AU    Louisirirotchanakul S; Wasi C; Surisance V; Kanoksinsombat C; Young N;
       Vanichseni S; Thongcharoen P; Faculty of Medicine Siriraj Hospital,
       Bangkok, Thailand.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):289 (abstract no. PC0076). Unique
       Identifier : AIDSLINE ICA10/94370069
 AB    OBJECTIVE: To study on the HIV serotypes in Thailand during 1985-1994,
       by using a high specific V3 peptide based enzyme immunoassay. METHODS:
       From 1985-1994, a total of 307 anti HIV-1 positive sera collected from
       30 homo/bisexual, 145 heterosexual and 132 intravenous drug users (IVDU)
       were studied the serotypes based on the synthetic V3. The antigen,
       derived from 15 amino acid of the V3 loop peptides from Thai genotype A
       and Thai genotype B as previous described, were provided from CDC,
       Atlanta, USA. RESULTS: The two serotypes of HIV-1 are circulating in
       Thailand. The genotype Thai A or subtype E was introduced lately since
       1988 and predominate in the sexual transmission group i.e. 85% while
       genotype Thai B or subtype B was found in 1987 and predominate among
       IVDU i.e. 73%. There were some sera which were not reacted with the two
       peptides. DISCUSSION AND CONCLUSION: The epidemic of HIV-1 just started
       in Thailand, during 1985-1986 only few cases of homosexual were found
       positive. The outbreak in IVDU was notified in the early of 1988 and
       spread to the heterosexual. The subtypes difference was found in the
       sexual and injection transmission route. The subtype E which introduced
       in 1988 showed the strong predominate now. This findings are important
       for the effective vaccine design.
 DE    Human  HIV Seropositivity/*MICROBIOLOGY  HIV-1/*CLASSIFICATION
       Serotyping  Thailand  MEETING ABSTRACT

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