Document 2542
 DOCN  M94A2542
 TI    Migration and HIV-1 seroprevalence in a rural Ugandan population.
 DT    9412
 AU    Nunn AJ; Kamali A; Kengeya-Kayondo JF; Mulder DW; MRC(UK) Programme on
       AIDS in Uganda/Uganda Virus Research; Institute, Entebbe.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):280 (abstract no. PC0040). Unique
       Identifier : AIDSLINE ICA10/94370033
 AB    OBJECTIVES: To study the association between change of residence and
       HIV-1 serostatus in a rural Ugandan population. METHODS: As part of the
       annual surveillance of a population cohort of approximately 10,000
       persons in a rural sub-county of South West Uganda information has been
       collected on change of residence of all adults over a three year period
       and its association with HIV-1 serostatus. Sera were collected by a
       medical team during home visits. Antibody testing was performed at the
       Uganda Virus Research Institute using two independent EIA systems and
       western blot when appropriate. RESULTS: At the fourth survey round age
       and sex standardised seroprevalence rates were 8.0% overall; the rate
       was 5.5% for 2,130 who had not changed house since the first survey,
       8.2% for 336 who moved within the village, 12.4% for 128 who moved to a
       neighbouring village and 16.3% for 542 who had joined the study area
       during the previous three years (P << 0.001, 3df). We also observed an
       inverse relationship between years lived at the present house at the
       time of the first survey and both seroprevalence and subsequent
       seroincidence rates. During 3 years the standardised rate for those
       remaining in the same residence fell from 8.2% to 5.5%. There was no
       evidence that change of residence was on account of HIV-1 associated
       death nor that those who joined were more likely to have come from a
       risk arena. CONCLUSION: Change of residence is strongly associated with
       an increased risk of HIV-1 infection in this rural population and is
       likely to be the result of more risky sexual behaviour among those who
       move. These findings need to be recognised when designing AIDS control
       programmes and intervention studies.
 DE    Cohort Studies  Human  *HIV Seroprevalence  *HIV-1  Risk Factors  Rural
       Population  *Transients and Migrants  Uganda/EPIDEMIOLOGY  MEETING
       ABSTRACT

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