Document 2580
 DOCN  M94A2580
 TI    Trends in recent HIV-1 infection among patients at sentinel hospitals,
       1988-1992.
 DT    9412
 AU    Weber JT; Satten GA; Hanson DL; Schable CA; Janssen RS; CDC, Atlanta,
       Georgia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):271 (abstract no. PC0001). Unique
       Identifier : AIDSLINE ICA10/94369995
 AB    OBJECTIVE: To use low beta 2-microglobulin (beta 2M) as a marker of
       recent HIV-1 infection to estimate trends in recent HIV-1 infection in
       communities served by 30 U.S. acute-care hospitals from 1988-1992.
       METHODS: To collect a sample resembling the general U.S. adult
       population, blood specimens were collected from an age- and
       sex-stratified sample of patients > or = 15 years old with conditions
       not associated with HIV-1. Specimens were tested anonymously for HIV-1
       antibody; positive specimens were tested for beta 2M. beta 2M < 2.1 mg/L
       (low beta 2M) was considered a marker for recent infection. We used
       logistic regression to estimate trends in low beta 2M. RESULTS: Trends
       in low beta 2-microglobulin among Sentinel Hospitals TABULAR DATA, SEE
       ABSTRACT VOLUME. Predominant (> 50%) exposure category of AIDS cases
       reported by hospital: male-male sex (MMS), injecting drug use (IDU), or
       both. Some hospitals had no HIV-1 positive specimens among women.
       DISCUSSION AND CONCLUSIONS: Incidence of HIV-1 infection among men, as
       measured by low beta 2M, appears to be decreasing in many communities
       served by sentinel hospitals, especially those that reported IDU as a
       major exposure category for AIDS cases.
 DE    beta 2-Microglobulin/ANALYSIS  Acquired Immunodeficiency
       Syndrome/DIAGNOSIS/*EPIDEMIOLOGY  Adult  AIDS Serodiagnosis  Biological
       Markers/BLOOD  Female  Hospitals/*STATISTICS & NUMER DATA  Human  *HIV-1
       Incidence  Male  Population Surveillance  Risk Factors  United
       States/EPIDEMIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).