Document 2581
 DOCN  M94A2581
 TI    Trends in distribution of HIV infection by risk factors in French
       Brittany 1990-1993.
 DT    9412
 AU    Cartier F; Favre C; Michelet C; Arvieux C; Camus C; Ruffault A; Dept. of
       Infect. Diseases, University Rennes, France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):271 (abstract no. PC0005). Unique
       Identifier : AIDSLINE ICA10/94369994
 AB    Actions of prevention of HIV disease are based upon the distribution of
       infected persons by risk category. Most of studies deal with new AIDS
       patients, years after infection. An earlier assessment, at the time of
       HIV serological detection is necessary. Such data have not been
       extensively reported and time between infection and serological
       detection was usually unknown. The aim of the study was to define trends
       in distribution of HIV infection by risk factors through the analysis of
       new seropositive patients, taking in account the previous duration of
       infection. All the patients seen at our hospital less than 4 months
       after ascertained new HIV seropositivity were prospectively studied:
       risk factor, previous duration of infection according to: 1. anamnestic
       findings and previous serological tests (infection < 6 months, > 2
       years) 2. clinical stage 3. P24 Ag, 4. CD4 T cells. 134 patients in
       1990-1991 (B) and 96 patients in 1992-1993 (C) were enrolled. Comparison
       between the 2 groups and with 197 new AIDS patients reported in
       1990-1993 in the same region (A) was made according to risk factors and
       criteria of duration of infection (chi 2 and t tests). Ratio of
       heterosexuality has increased 8.6% (A), 19.4% (B), 20.8% (C), B+C vs A:
       p < 0.001, C vs A: p < 0.01. Ratio of IVDU was 22.8% (A), 17.9% (B),
       14.6% (C): N.S., and that of blood products recipients (BPR) was 5.6%
       (A), 4.3% (B), 3.1% (C): N.S. Together, these 2 last categories have
       decreased: C vs A: p < 0.05. Previous duration of infection was longer
       in C than B, according to criterion 4: CD4 T cells 395 vs 591: p < 0.01.
       It was longer in all IVDU (B+C) than in all homosexuals (criteria 1 and
       3), in all BPR than in all homosexuals (criterion 1), in all homosexuals
       than in all heterosexuals (criterion 4). CONCLUSION--Heterosexuality
       risk is relatively increasing. Longer previous duration of infection in
       recent new seropositive patients suggests a decreasing incidence of HIV
       transmission in our country, particularly in IVDU and homosexuals.
 DE    Blood Transfusion/ADVERSE EFFECTS  France/EPIDEMIOLOGY  Homosexuality
       Human  HIV Infections/*EPIDEMIOLOGY/TRANSMISSION  HIV Seropositivity
       Risk Factors  Substance Abuse, Intravenous/COMPLICATIONS  MEETING
       ABSTRACT

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