Document 2591
 DOCN  M94A2591
 TI    A comparison of cervical abnormalities in HIV infected and uninfected
       pregnant women.
 DT    9412
 AU    Connor J; Mitchell JL; Lockhart M; Loftman PO; Carrington B; Matseaone
       S; Harlem Hospital Center, New York.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):27 (abstract no. 080B). Unique
       Identifier : AIDSLINE ICA10/94369984
 AB    OBJECTIVE: To compare the rates and severity of cervical abnormalities
       of HIV infected and uninfected women seen in a prenatal clinic for drug
       users controlling for age, parity, history of STD'S, Human papilloma
       virus, and type and route of drug use. METHODS: Charts of women who
       received care in a special prenatal clinic for drug abusers (N = 1300)
       were reviewed for PAP smear results, history and current STD status,
       age, parity, drug use. HIV infected women were divided into 3 groups-CD4
       counts > 500, CD4 counts between 500 & 200, and CD4 counts < 200 and
       matched to HIV uninfected women with similar characteristics. RESULTS:
       The HIV infection rate for the clinic is 20%. Cervical abnormalities
       were found in 33% of the total uninfected group but in 63% of the
       infected group. In the HIV infected group with abnormalities, 16% had
       evidence of HPV infection, compared to 6% of the uninfected group.
       However, preliminary analyses of the first 210 matched pairs suggest
       that the HIV infected group with CD4 > 500 had rates of abnormalities
       (36%) comparable to the uninfected group. The group with CD4 500-200 had
       a rates of approx. 46%. The group with CD4 < 200 had rates of 96% and
       the severest abnormalities. In the CD4 > 500, heroin and age > 30 was
       associated with abnormalities more than non-heroin use and age < 30.
       DISCUSSION AND CONCLUSION: Most studies of cervical abnormalities in HIV
       infected women have not used as a comparison a group of women match for
       similar characteristics but not HIV infected. Many of these
       characteristics increases the risk of cervical abnormalities without HIV
       infection. Better understanding of the impact of these characteristics
       is needed.
 DE    Age Factors  Cervix Diseases/MICROBIOLOGY/*PATHOLOGY  Female  Heroin
       Dependence/COMPLICATIONS  Human  HIV Infections/*PATHOLOGY  Leukocyte
       Count  Papillomavirus, Human/ISOLATION & PURIF  Papovaviridae
       Infections/MICROBIOLOGY  Pregnancy  Pregnancy Complications,
       Infectious/*PATHOLOGY  Tumor Virus Infections/MICROBIOLOGY  T4
       Lymphocytes  *Vaginal Smears  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).