Document 2611
 DOCN  M94A2611
 TI    High cumulative incidence of genital herpes amongst HIV-1 seropositive
       heterosexuals in south London.
 DT    9412
 AU    O'Farrell N; Tovey SJ; Lloyd Clinic, Guy's Hospital, London, UK.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):265 (abstract no. PB0488). Unique
       Identifier : AIDSLINE ICA10/94369964
 AB    OBJECTIVE: To determine the cumulative incidence of sexually transmitted
       diseases (STD) amongst a cohort of HIV-1 seropositive heterosexuals in
       South London, England. METHODS: Retrospective review of case notes in 51
       (35 female, 16 male) HIV-1 positive subjects attending an STD clinic who
       had acquired HIV-1 infection via heterosexual transmission to August
       1993. RESULTS: Thirty one (88%) of the women and 13 (81%) of the men
       were of sub Saharan African origin. Approximately half of the subjects
       were first diagnosed as HIV-1 positive with CD4 counts < 200 x 10(6)/1
       and a quarter with CD4 counts < 50 x 10(6)/1. STD detected in women
       were: genital herpes 15 (43%), candida 12 (34%), bacterial vaginosis 9
       (25%), and in men: genital herpes 6 (38%, non-gonococcal urethritis 4
       (25%). No cases of gonorrhoea were detected. At the time of first
       diagnosis of genital herpes at the clinic, the mean CD4 count in women
       was 275 x 10(6)/1 and in men 285 x 10(6)/1. Genital herpes was the AIDS
       defining diagnosis in three of the women. CONCLUSIONS: The recognised
       risk of HIV transmission via genital lesions should be stressed in HIV-1
       positive subjects with genital herpes. The incidence of other STD was
       very low--both knowledge of HIV status and safer sex counselling may
       limit riskful sexual behaviour and should be evaluated further as a
       strategy for limiting the spread of HIV-1 infection.
 DE    Cross-Sectional Studies  Female  Herpes
       Genitalis/COMPLICATIONS/*EPIDEMIOLOGY/TRANSMISSION  Human  HIV
       Seropositivity/COMPLICATIONS/*EPIDEMIOLOGY/TRANSMISSION  *HIV-1
       Incidence  London/EPIDEMIOLOGY  Male  Risk Factors  Sex Behavior  Urban
       Population/*STATISTICS & NUMER DATA  MEETING ABSTRACT

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