Document 2616
 DOCN  M94A2616
 TI    Peculiarities of clinical manifestations and course of syphilis in
       HIV-infected patients.
 DT    9412
 AU    Potekayev N; Potekayev S; Gruzdev B; Specialized Research Laboratory for
       AIDS Epidemiology and; Prevention, Russia AIDS Research Centre, Moscow.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):263 (abstract no. PB0482). Unique
       Identifier : AIDSLINE ICA10/94369959
 AB    OBJECTIVE: To detect peculiarities of clinical manifestations and course
       of syphilis in HIV-infected patients. METHODS: In 63 patiens (female 3,
       male 60, aged 17-52; 2--primary, 33--secondary, 22--early latent,
       6--late latent syphilis) the diagnosis of HIV infection was confirmed
       with ELISA and Western blot and of syphilis on basis of detection of T.
       pallidum, express-method, complement linkage reaction, FTA-abs, FTA-200,
       immobilization reaction in blood and CSF and clinical examinations and
       when necessary histological studies. RESULTS: Chancre was found in 3
       patients: in 1--erosive (in the fold of ani), in 1--phagedenic (in the
       right angle of the mouth) and in 1--gangrenous (in the back lesion of
       vagina). The secondary syphilids were distinguished by rich dark red
       colour, hemorages and petechias; 9 such patients had psoriasiform
       papules, 1--flat nodules. In the latter (woman) in the course of time
       Kaposi sarcoma developed. The areas of specific alopecia in 1 patient
       was up to 5 cm in D. Wassermann reaction often was false-negative, CSF
       examinations clearly showed early involvement of nervous system in
       syphilis. CONCLUSION: Syphilis in combination with HIV-infection is
       distinguished with more rapid course, clear vessel component in
       secondary syphilis, unusual clinical features and early asymptomatic
       involvement of nervous system.
 DE    Adolescence  Adult  AIDS Serodiagnosis  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS  Chancre/DIAGNOSIS  Female  Human  HIV
       Infections/*DIAGNOSIS  Male  Middle Age  Predictive Value of Tests
       Syphilis/*DIAGNOSIS  Syphilis Serodiagnosis  MEETING ABSTRACT

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