Document 2618
 DOCN  M94A2618
 TI    Evaluation of effectiveness of treating various form of syphilis in
       HIV-infection with large doses of intramuscular benzylpenicillin.
 DT    9412
 AU    Gruzdev BM; Potekaev SN; Potekaev NS; Moscow AIDS clinical Centre,
       Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):263 (abstract no. PB0481). Unique
       Identifier : AIDSLINE ICA10/94369957
 AB    PURPOSE: To determine effectiv therapeutical approach to syphilis in
       HIV-infected patients. METHODS: In 14 patients (female-1, male 13 aged
       from 21 to 42; primari siphilis-1 (re-infection), secondary-7
       (re-infection in 1), latent-6 (re-infection in 1), the diagnosis of
       HIV-infection was confirmed with ELISA and Western blot, of
       syphilis-with detection of T. Pallidum express-method, complement
       linkage reaction (CLR) with both antigens. FTA-ABS, FTA-200,
       immobilization reaction (IR), and when necessary--with histological
       studies. The method of therapy made by the authors was use:
       benzylpenicillin im by 4 million IU every 4h for 14 days (course dose
       336 million IU). Clinikal and serological control after the finishing of
       therapy was performed for 1.5 yrs: CLR-bimonthly; FTA-200, FTA-abs and
       IR-sixmonthly. In 2 (1-latent, 1-secondary syphilis) the therapy was
       censed due to acute pain in the sites of injections. RESULTS: The
       tolerance of the method was 80%. In primary syphilis (re-infection) the
       decline in positive intensiveness and in titer of CLR was seen with the
       absence of dynamics of FTA-200, FTA-abs and IR. In 4 patients with
       secondary syphilis CLR became negative in average 4 mos after the
       finishing therapy, in 2-decline in positive intensiveness and in titer
       of CLR was seen, 1 (re-infection) became seroresistent. In
       latentsyphilis seronegativation in CLR was seen in 3 after 5.5 mos, the
       decline in positive intensiveness and in titer of CLR was seen in 1 and
       seroresistence--in 1. In secondary and latent syphilis FTA-200, FTA-abs
       adynamic and IR declined in average by 40% for 1.5 yrs. CONCLUSIONS: The
       large doses method of therapy was effective in 83% HIV-infected patients
       with varios forms of syphilis. The posttreatment seroresiitens coincided
       with reinfection of syphilis (2 from 3 pts). The effective therapy of
       syphilitic seroresistens in HIV-infection remains to be determined.
 DE    Adult  AIDS-Related Opportunistic Infections/*DRUG THERAPY/TRANSMISSION
       Dose-Response Relationship, Drug  Drug Administration Schedule  Female
       Human  HIV Infections/*DRUG THERAPY/TRANSMISSION  Injections,
       Intramuscular  Male  Penicillin G/*ADMINISTRATION & DOSAGE  Recurrence
       Russia  Syphilis/*DRUG THERAPY/TRANSMISSION  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).