Document 2624
 DOCN  M94A2624
 TI    Pentamidine pharmacokinetics in a neonate and his mother with AIDS.
 DT    9412
 AU    Schwebke K; Fletcher C; Acousta E; Henry K; St. Paul-Ramsey Medical
       Center, Minn.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):261 (abstract no. PB0473). Unique
       Identifier : AIDSLINE ICA10/94369951
 AB    OBJECTIVE: To describe pentamidine pharmacokinetics in a woman with AIDS
       and her newborn infant while the mother was receiving treatment for
       Pneumocystis carinii pneumonia (PCP). METHODS: (Case Report): A
       21-year-old HIV seropositive female who was 32 weeks pregnant was
       hospitalized with PCP (CD4 count = 196). TMP-SMZ was stopped due to
       adverse events and she was placed on i.v. pentamidine 200mg each day
       (weight = 58.1 kg). Due to progressive worsening of the mother's medical
       status, the neonate was delivered by C-section. Blood specimens for
       pentamidine concentration were sent that day from the mother and neonate
       (cord blood). RESULTS: The mother's pentamidine concentration 8 hours
       after her 7th dose was 81.3 mcg/L (a simulation model predicted 3-76
       mcg/L). The infant's concentration drawn 16.5 hours after the mother's
       7th dose was 13.2 mcg/L (Table 1). CONCLUSION: Present knowledge of the
       pharmacokinetics of placental transfer of antimicrobial agents used in
       the treatment of HIV/AIDS related infections is very limited. Data
       regarding placental transfer of pentamidine is limited to data from in
       vitro or animal models. In this report, in vivo placental transfer of
       pentamidine was observed. Networks to further study maternal-fetal
       pharmacokinetics of medications used in the treatment and prophylaxis of
       HIV-related complications need to be established.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD/DRUG THERAPY/  TRANSMISSION
       Adult  AIDS-Related Opportunistic Infections/*BLOOD/DRUG THERAPY/
       TRANSMISSION  Case Report  Cesarean Section  Female  Fetal
       Blood/*METABOLISM  Human  Infant, Newborn  Infusions, Intravenous
       Maternal-Fetal Exchange/*PHYSIOLOGY  Metabolic Clearance Rate/PHYSIOLOGY
       Pentamidine/ADMINISTRATION & DOSAGE/*PHARMACOKINETICS  Pneumonia,
       Pneumocystis carinii/*BLOOD/DRUG THERAPY/TRANSMISSION  Pregnancy
       Pregnancy Complications, Infectious/*BLOOD/DRUG THERAPY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).