Document 2626
 DOCN  M94A2626
 TI    Maternal-infant transmission of hepatitis C virus and HIV infection.
 DT    9412
 AU    Maccabruni A; Bossi G; Caselli D; Mondelli M; Cerino A; Silini E;
       Department of Infectious Diseases, IRCCS Policlinico San Matteo,; Pavia,
       Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):261 (abstract no. PB0474). Unique
       Identifier : AIDSLINE ICA10/94369949
 AB    As a part of an ongoing study about vertical transmission of HCV and the
       possible interaction between HIV 1 and HCV, during the last 6 years we
       have followed-up 87 child-bearing women (age 19-45 yr) and their 94
       children (age 1 mos-9 yr). Sera from all mother-child pairs were
       screened for HCV and HIV 1 antibodies by EIA: samples of
       HCV-seropositive mothers and of their children were submitted for HCV
       genomic analysis by PCR. We detected specific HCV antibodies in 48/87
       women (55%); 41/48 of them (85%) were also HIV 1 infected. Out of the 41
       HIV 1/HCV coinfected women, 38 (93%) had been IVDU and 4 (7%) were
       etherosexually infected. PCR for HCV-RNA, performed in 18 of them, was
       positive, evidencing multiple HCV infection in 4/18 (22%) cases (IVDU).
       Type I HCV was detected in 10/18 women (55%), type II in 4/18 (22%),
       type III in 2/18 (11%), type V in 7/18 (39%) and type IV in none case.
       7/47 (15%) HCV-seropositive women were HIV 1 negative: 4 (57%) had been
       IVDU, 2 (28%) had a history of parenteral exposure and 1 (14%) was
       etherosexually infected. PCR, performed in 5/7 cases, was positive, with
       evidence of multiple infection only in one case (IVDU). Type I HCV was
       detected in 3/5 women (60%), type III in 2/5 (40%), type V in 2/5 (40%),
       type II and IV in none case. 9/52 (17%) children born to
       HCV-seropositive women were HCV infected. All the HCV infected children
       had HIV 1 seropositive mothers but none of them resulted HIV 1
       coinfected. Only in 1/9 cases (11%) HCV-PCR was discordant with
       serologic test. Up today we found a single case of HCV vertical
       transmission in which the HCV variant of the child doesn't match that of
       the mother.
 DE    Adult  AIDS Serodiagnosis  Child  Child, Preschool  Female  Follow-Up
       Studies  Hepatitis C/DIAGNOSIS/*TRANSMISSION  Human  HIV
       Infections/DIAGNOSIS/*TRANSMISSION  *HIV-1  Infant  Infant, Newborn
       Male  Middle Age  Polymerase Chain Reaction  Predictive Value of Tests
       Pregnancy  Pregnancy Complications, Infectious/*DIAGNOSIS  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).