Document 2627
 DOCN  M94A2627
 TI    Maternal risk factors in HIV vertical transmission.
 DT    9412
 AU    Maccabruni A; Caselli D; Bossi G; Calderon W; Degioanni M; Gatti M;
       Comolli G; Department of Infectious Diseases, IRCCS Policlinico San
       Matteo,; Pavia, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):261 (abstract no. PB0475). Unique
       Identifier : AIDSLINE ICA10/94369948
 AB    Several reports suggest that vertical HIV transmission may be related to
       the mother's immunological, virological and clinical status. To
       investigate the possible role of these maternal factors we analyzed the
       data obtained from 34 HIV seropositive women (20 IVDU and 14
       etherosexually infected; 10 multipara) during pregnancy and at delivery
       and from their offspring in the years 1991-1993. At delivery HIV p24
       Antigen resulted as follows: 21 NEGATIVE; 6 BORDER-LINE CONCENTRATION
       (30 pg/ml); 1 50 pg/ml; 3 > = 100 pg/ml; 3 NOT EFFECTED. CD4+ count was
       < 200/mmc in 1/10 Ag p24 positive mothers, 300-500/mmc in 6/10 and >
       600/mmc in 3/10. All these mothers resulted non transmitting.
       Nevertheless two of them had transmitted HIV infection during a previous
       pregnancy, when they were Ag p24 negative and clinically asymptomatic.
       We demonstrated HIV vertical transmission in 3 mother-child pairs, where
       the mothers resulted Ag p24 negative and showed CD4+ count > 400/mmc
       during the last trimester of pregnancy and at delivery. Our
       retrospective study shows no significant correlation between maternal
       immunological and virological parameters and rates of HIV vertical
       transmission. Moreover maternal HIV-related symptoms don't seem to be
       associated with an highest rate of vertical transmission of infection.
 DE    AIDS Serodiagnosis  Female  Human  HIV Core Protein p24/BLOOD  HIV
       Infections/IMMUNOLOGY/*TRANSMISSION  Infant, Newborn  Leukocyte Count
       Pregnancy  Pregnancy Complications, Infectious/*DIAGNOSIS/IMMUNOLOGY
       Retrospective Studies  Risk Factors  T4 Lymphocytes/IMMUNOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).