Document 2629
 DOCN  M94A2629
 TI    Macrophages' function in the treatment of HIV 1 infected children.
 DT    9412
 AU    Sizyakina LP; Chernyshov VN; Simovanian EN; Shemshura AB; Denisenko VB;
       Medical Institute, Rostov-on-Don, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):260 (abstract no. PB0469). Unique
       Identifier : AIDSLINE ICA10/94369946
 AB    A total of 53 children aged 3-10 years having the diagnosis of HIV-1
       infection were examined. 33 patients (14--at the stage of primary
       symptoms, 19--at the stage of secondary diseases) were given retrovir
       180 mg/m2, 4 times per day. The rest 20 patients (7-at the stage of
       primary symptoms, 13--at the stage of secondary diseases) were not given
       retrovir. It was established that retrovir was more effective at the
       early stage of HIV-1 infection. The application of retrovir at the stage
       of primary symptoms leads to the reducing of the increasea expression of
       FcR and C3bR in monocytes, to the slight diminution of their absorbing
       ability and intensity of oxygendependent metabolism alongside with the
       simultaneous increase of the reserved potentials, digesting activity and
       secretion of IL-1. The application of retrovir at the stage of secondary
       diseases allows to preserve considerable reserved potentiaes of
       macrophages, their ability to synthesize IL-1, but at the same time it
       causes the following suppression of C3bR expression and the marked
       supression of phagocytosis. In all patients gene pol expression was
       detected.
 DE    Child  Child, Preschool  Female  Human  HIV Infections/*DRUG
       THERAPY/IMMUNOLOGY  HIV-1/*DRUG EFFECTS/IMMUNOLOGY
       Interleukin-1/BIOSYNTHESIS  Macrophage Activation/DRUG
       EFFECTS/IMMUNOLOGY  Macrophages/*DRUG EFFECTS/IMMUNOLOGY  Male
       Phagocytosis/DRUG EFFECTS/IMMUNOLOGY  Zidovudine/*ADMINISTRATION &
       DOSAGE  MEETING ABSTRACT

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