Document 2637
 DOCN  M94A2637
 TI    Neurological manifestations of HIV infection-AIDS in children.
 DT    9412
 AU    Matusa R; Ilie M; Cernescu C; Borcea A; Marinescu S; Municipal Hospital
       Constanta, Bucharest.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):259 (abstract no. PB0467). Unique
       Identifier : AIDSLINE ICA10/94369938
 AB    OBJECTIVE: To observe the neurological manifestations in HIV
       infected-AIDS children. METHODS: We have retrospectively reviewed our
       cohort of 600 children with HIV infection-AIDS from Constanta, ages 2
       months to 7 years. We use clinical study, neurological exam, head
       circumference, the DENVER, test, the cerebrospinal fluid (CSF) exam,
       computed tomography (CT), and neuropathologic findings. RESULTS:
       Neurological manifestations: progressive encephalopathy (15%), static
       encephalopathy (40%), seizures (40%), TB meningoencephalitis (8 cases),
       bacterial or fungal meningitis, acute aseptic meningitis. Cerebrospinal
       Fluid Findings: lymphocytic pleocytosis, and elevations of protein;
       detection of HIV-1 core antigen and synthesis of HIV-1 specific
       antibodies. Cerebral atrophy, microcephaly were detected by CT scanning
       or postmortem. DISCUSSION AND CONCLUSIONS: Central nervous system
       involvement in HIV infected children is a frequent and heterogeneous
       manifestation.
 DE    Acquired Immunodeficiency Syndrome/*DIAGNOSIS  AIDS Dementia
       Complex/*DIAGNOSIS  AIDS-Related Opportunistic Infections/*DIAGNOSIS
       Brain/PATHOLOGY  Child  Child, Preschool  Cohort Studies  Female
       Follow-Up Studies  Human  HIV Infections/*DIAGNOSIS  Infant  Male
       Meningitis/*DIAGNOSIS  *Neurologic Examination  Tomography, X-Ray
       Computed  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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