Document 2638
 DOCN  M94A2638
 TI    Neurological manifestation in parenterally HIV-1 infected children in
       Russia.
 DT    9412
 AU    Rakhmanova A; Fomin J; Chernykh M; Popova I; Burova N; Fomina M; Russian
       Clinical HIV-AIDS center, St.-Petersburg.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):259 (abstract no. PB0466). Unique
       Identifier : AIDSLINE ICA10/94369937
 AB    OBJECTIVE: The prevalence of central nervous system (CNS) disease in
       HIV-1 infected children have been reported in several series to vary
       between 8% and 62%. The aim was to describe CNS diseases in russian
       children infected HIV-1 by parenteral route. METHODS: 76 HIV-1 infected
       children were enrolled in surveillance from 1/91 to 10/93 year. The most
       of them were in 5-7 year age group. All children were infected HIV-1
       five years ago in hospitals where they were with any serious illnesses.
       Clinical histories were reviewed to collect data. At time of the
       analyses 45 patients had ARC, 16--AIDS, 8--have died. RESULTS: Of 76
       enrolled children 64 (81.5%) have had signs of CNS disease (delay
       psychomotor and language developing, neurological signs). Fifty one from
       those 64 patients before expose to HIV have had multiply risk factor for
       encephalopathy due to events in perinatal period (prematurity, in utero
       infections, severe hypoxic injury). 8 (12.5%) patients have had
       HIV-related encephalopathy diagnosed by clinical exams and computed
       tomographic scans. 6 children with HIV-related CNS disease were
       long-treated by oral Retrovir (Wellcome) and have surviving more than 2
       years without progression CNS symptoms. Two other patients have not been
       treated and died in 6-9 month after HIV-related encephalopathy have been
       diagnosed. CONCLUSION: 1. The diagnose of HIV-related CNS disease was
       difficult for multiply risk factor preceding HIV infection. 2. Retrovir
       was useful for treatment HIV-related encephalopathy in children.
 DE    AIDS Dementia Complex/*DIAGNOSIS  Child  Child, Preschool  Follow-Up
       Studies  Human  HIV Infections/*DIAGNOSIS/TRANSMISSION  *HIV-1
       *Neurologic Examination  Risk Factors  Russia  MEETING ABSTRACT

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