Document 2649
 DOCN  M94A2649
 TI    Paediatric HIV diagnosis in the Malaysian context.
 DT    9412
 AU    Sinniah M; Institute for Medical Research, Kuala Lumpur, Malaysia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):256 (abstract no. PB0454). Unique
       Identifier : AIDSLINE ICA10/94369926
 AB    OBJECTIVE: To evaluate diagnostic approaches for paediatric HIV
       laboratory diagnosis in order to adopt the most suitable for use in the
       Malaysian setting. MATERIALS & METHODS: Sera from babies suspected to be
       HIV infected or born to HIV positive mothers were tested using Anti HIV
       1 & 2 Elisa, HIV-Antigen Elisa and PCR. Follow up sera were tested where
       available. RESULTS: All the 17 babies in our study had HIV Antibodies.
       Diagnosis was established in most cases by persisting antibody levels at
       follow-up; by PCR when that became available locally, and by a positive
       HIV-Ag assay in only some of the cases. DISCUSSION & CONCLUSION: A
       combination of tests seems suitable in the Malaysian context, due to the
       technical difficulties inherent in these assays, as well as due to
       sociocultural factors leading to defaulted follow-up.
 DE    *Developing Countries  Enzyme-Linked Immunosorbent Assay  Female
       Follow-Up Studies  Human  HIV Antibodies/BLOOD  HIV Antigens/BLOOD  HIV
       Infections/*DIAGNOSIS/IMMUNOLOGY/TRANSMISSION  Infant  Infant, Newborn
       Malaysia  Polymerase Chain Reaction  Pregnancy  MEETING ABSTRACT

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